Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2898972..2899626 Replicon chromosome
Accession NC_011740
Organism Escherichia fergusonii ATCC 35469

Toxin (Protein)


Gene name cptA Uniprot ID B7LPA9
Locus tag EFER_RS14265 Protein ID WP_000244784.1
Coordinates 2898972..2899379 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EFER_RS14270 Protein ID WP_000354046.1
Coordinates 2899360..2899626 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFER_RS14245 2894929..2896662 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
EFER_RS14250 2896668..2897378 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EFER_RS14255 2897403..2898299 - 897 WP_000806646.1 site-specific tyrosine recombinase XerD -
EFER_RS14260 2898411..2898932 + 522 WP_001055871.1 flavodoxin FldB -
EFER_RS14265 2898972..2899379 - 408 WP_000244784.1 protein YgfX Toxin
EFER_RS14270 2899360..2899626 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EFER_RS14275 2899878..2900858 + 981 WP_000886105.1 tRNA-modifying protein YgfZ -
EFER_RS14280 2900935..2901594 - 660 WP_000250283.1 hemolysin III family protein -
EFER_RS14285 2901758..2902069 - 312 WP_001182961.1 N(4)-acetylcytidine aminohydrolase -
EFER_RS14290 2902114..2903547 + 1434 WP_024256520.1 6-phospho-beta-glucosidase BglA -
EFER_RS14295 2903595..2904488 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16094.05 Da        Isoelectric Point: 11.2511

>T23313 WP_000244784.1 NC_011740:c2899379-2898972 [Escherichia fergusonii ATCC 35469]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T23313 NC_011740:c2899379-2898972 [Escherichia fergusonii ATCC 35469]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACTCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATTCCCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT23313 WP_000354046.1 NC_011740:c2899626-2899360 [Escherichia fergusonii ATCC 35469]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT23313 NC_011740:c2899626-2899360 [Escherichia fergusonii ATCC 35469]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7LPA9

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References