Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3229506..3230020 Replicon chromosome
Accession NZ_CP091318
Organism Methylocystis sp. SB2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LNB28_RS15710 Protein ID WP_029650264.1
Coordinates 3229694..3230020 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LNB28_RS15705 Protein ID WP_026223051.1
Coordinates 3229506..3229694 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNB28_RS15685 (LNB28_15685) 3224798..3225634 + 837 WP_239755481.1 UDP-3-O-acyl-N-acetylglucosamine deacetylase -
LNB28_RS15690 (LNB28_15690) 3225804..3226688 + 885 WP_036241769.1 outer membrane protein assembly factor BamD -
LNB28_RS15695 (LNB28_15695) 3226685..3227581 - 897 WP_029650268.1 alpha/beta hydrolase -
LNB28_RS15700 (LNB28_15700) 3227694..3229373 + 1680 WP_029650266.1 DNA repair protein RecN -
LNB28_RS15705 (LNB28_15705) 3229506..3229694 + 189 WP_026223051.1 antitoxin MazE family protein Antitoxin
LNB28_RS15710 (LNB28_15710) 3229694..3230020 + 327 WP_029650264.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LNB28_RS15715 (LNB28_15715) 3230072..3230944 + 873 WP_029650262.1 chorismate mutase -
LNB28_RS15720 (LNB28_15720) 3230950..3231375 - 426 WP_029650260.1 type II toxin-antitoxin system VapC family toxin -
LNB28_RS15725 (LNB28_15725) 3231372..3231881 - 510 WP_051381759.1 hypothetical protein -
LNB28_RS15730 (LNB28_15730) 3232025..3233155 + 1131 WP_029650256.1 histidinol-phosphate transaminase -
LNB28_RS15735 (LNB28_15735) 3233148..3234071 + 924 WP_239754230.1 prephenate/arogenate dehydrogenase family protein -
LNB28_RS15740 (LNB28_15740) 3234113..3234808 + 696 WP_029650252.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin MazE-like

(2-59)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11403.25 Da        Isoelectric Point: 5.0322

>T233122 WP_029650264.1 NZ_CP091318:3229694-3230020 [Methylocystis sp. SB2]
MRRGAFVVVATSGDYGKPRPALVVQSDLFAELPSVVICPLTTTLRGDADLFRLDVEPSAGNGLRQASQIAVDKLTVVPSS
KIGEVIGEADDALLLRVNRALALFLGIV

Download         Length: 327 bp

>T233122 NZ_CP128532:c800586-800362 [Mannheimia haemolytica]
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACACTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCGAATCCTGATACAGATAAGGGGCGGTAG

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7174.16 Da        Isoelectric Point: 6.4497

>AT233122 WP_026223051.1 NZ_CP091318:3229506-3229694 [Methylocystis sp. SB2]
MASYRQRMRAAGLRPVQIWAPDSRAPDFIEKCHRQARAVAIHDPAGDEIMQFVASMYEWPED

Download         Length: 189 bp

>AT233122 NZ_CP128532:c800319-799990 [Mannheimia haemolytica]
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTCATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGTGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References