Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2479608..2480191 Replicon chromosome
Accession NZ_CP091317
Organism Lysobacter soli strain RCu6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L3D22_RS11215 Protein ID WP_253335672.1
Coordinates 2479608..2479787 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L3D22_RS11220 Protein ID WP_253335673.1
Coordinates 2479796..2480191 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3D22_RS11200 (L3D22_11200) 2476678..2478132 - 1455 WP_253335669.1 DNA polymerase Y family protein -
L3D22_RS11205 (L3D22_11205) 2478142..2478798 - 657 WP_253335670.1 translesion DNA synthesis-associated protein ImuA -
L3D22_RS11210 (L3D22_11210) 2478798..2479418 - 621 WP_253335671.1 transcriptional repressor LexA -
L3D22_RS11215 (L3D22_11215) 2479608..2479787 + 180 WP_253335672.1 type II toxin-antitoxin system HicA family toxin Toxin
L3D22_RS11220 (L3D22_11220) 2479796..2480191 + 396 WP_253335673.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L3D22_RS11225 (L3D22_11225) 2480194..2481003 - 810 WP_253335674.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
L3D22_RS11230 (L3D22_11230) 2481058..2481867 - 810 WP_192630873.1 M28 family peptidase -
L3D22_RS11235 (L3D22_11235) 2482104..2482751 + 648 WP_115841569.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6347.49 Da        Isoelectric Point: 11.7888

>T233120 WP_253335672.1 NZ_CP091317:2479608-2479787 [Lysobacter soli]
MTKSADVIRDLERAGWTLARVSGSHHIFTKPGKPPISVPHPKKGLGAGLVHKLRKQAGL

Download         Length: 180 bp

>T233120 NZ_CP128532:c246925-246593 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14313.06 Da        Isoelectric Point: 4.3036

>AT233120 WP_253335673.1 NZ_CP091317:2479796-2480191 [Lysobacter soli]
MHYPIAIEHGDETHAFGVVVPDLPGCFSAGDTLEEAIVNATEAISLWLEDALDLTQAIPAPSPVDRWANDPEYQGWTFAL
VKVDPAALDDTIERVNITLPRRVLHRLDQRARAAGETRSGFIARLALNDAA

Download         Length: 396 bp

>AT233120 NZ_CP128532:c247182-246922 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References