Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1746836..1747424 Replicon chromosome
Accession NZ_CP091311
Organism Pseudomonas juntendi strain 18091276

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag L2Y89_RS08175 Protein ID WP_082437973.1
Coordinates 1747110..1747424 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag L2Y89_RS08170 Protein ID WP_054881879.1
Coordinates 1746836..1747129 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y89_RS08145 (L2Y89_08145) 1741858..1742733 + 876 WP_064314548.1 carboxylate/amino acid/amine transporter -
L2Y89_RS08150 (L2Y89_08150) 1742735..1743148 + 414 WP_009683095.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
L2Y89_RS08155 (L2Y89_08155) 1743228..1744529 - 1302 WP_009683094.1 mechanosensitive ion channel family protein -
L2Y89_RS08160 (L2Y89_08160) 1744633..1745994 + 1362 WP_237144623.1 DEAD/DEAH box helicase -
L2Y89_RS08165 (L2Y89_08165) 1746370..1746645 - 276 WP_054881878.1 hypothetical protein -
L2Y89_RS08170 (L2Y89_08170) 1746836..1747129 - 294 WP_054881879.1 putative addiction module antidote protein Antitoxin
L2Y89_RS08175 (L2Y89_08175) 1747110..1747424 - 315 WP_082437973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y89_RS08180 (L2Y89_08180) 1747602..1747997 + 396 WP_009683679.1 hypothetical protein -
L2Y89_RS08185 (L2Y89_08185) 1748104..1749030 + 927 WP_054881880.1 DMT family transporter -
L2Y89_RS28335 1749217..1749345 + 129 WP_009683677.1 PA1414 family protein -
L2Y89_RS08190 (L2Y89_08190) 1749475..1750854 - 1380 WP_054881881.1 sodium:solute symporter -
L2Y89_RS08195 (L2Y89_08195) 1750960..1751910 - 951 WP_054881882.1 agmatinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-95)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11771.50 Da        Isoelectric Point: 10.8773

>T233117 WP_082437973.1 NZ_CP091311:c1747424-1747110 [Pseudomonas juntendi]
MKKIESSSFRHWVSGLRDVSARTRIIARINRLMEGLPGDVSPVGHGVSELRVHYGPGYRVYFHQAGSTFVILLCGGDKSS
QQRDIKAAHHILRSWRMQNDTNLL

Download         Length: 315 bp

>T233117 NZ_CP128531:1494621-1494926 [Mannheimia haemolytica]
ATGTTTAACTTAACCGAAGCCCATTTTAGAGATGAAGCTCTTTATCGGTTCTTCCAATATGGCGAAGTCAGCAGAACAAT
CCCTGCTAATCTCACAAGCGTATTAGCTCGCAAACTGGATATGATTAATGCAGCTGAAAAGCTGAATGACTTACGCAGTC
CGCCTGCTAATCGCTTAGAGTTACTTGAGCCGAAACAGAACAACGTCTATTCAATTCGAGTAAACAAACAGTATCGATTG
ATTTTCAAGTTTGAAAACAATGAACTCTCTGATTTATACCTTGACCCACACAATTACGACCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10552.07 Da        Isoelectric Point: 6.7238

>AT233117 WP_054881879.1 NZ_CP091311:c1747129-1746836 [Pseudomonas juntendi]
MTQTFSEFDPAEYLTTPEAIAVFMTDALETGDARYVAKAVGVVARAKGMSELAKDTGLSREQLYRSFSEHGNPTLKSFLT
VMKALGIHMTARPHIAG

Download         Length: 294 bp

>AT233117 NZ_CP128531:1494938-1495258 [Mannheimia haemolytica]
ATGATGCAACGCAAACCGACCCCGGTTGGGGAAATTCTCCAGGAAGAATTTTTAGCGCCACTTAATCTTAAAATCGGCGA
CCTCGTTGAAATTTTAGACGTACACCGCAACACCGCCAGCAACCTTGTGAATAACAGTTGCCGTGTTAGTCCTGAAATGG
CATTTAAATTGGCAAAAGCCTTTGATACCAGCCCTGAATTTTGGCTCAACCTACAAACCGCAACCGATTTATGGGAACTC
CGCCATAACAACCGCTTCCAACAAAGCCTTGATAGCGTAAAAGCCGTAAATCACTGGCAAGGTGTGCCTGCATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References