Detailed information of TA system TA233111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1039813..1040332
• Replicon: chromosome
• Accession: NZ_CP091308
• Organism: Burkholderia pyrrocinia strain LWK2

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: L2Y90_RS22095
• Protein ID: WP_258284645.1
• Coordinates: 1039813..1040094 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0G3WYJ8
• Locus tag: L2Y90_RS22100
• Protein ID: WP_047902230.1
• Coordinates: 1040084..1040332 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Y90_RS22075 (L2Y90_22025)	1035420..1036118	-	699	WP_258284641.1	MgtC/SapB family protein	-
L2Y90_RS22080 (L2Y90_22030)	1036233..1037342	+	1110	WP_258284642.1	AGE family epimerase/isomerase	-
L2Y90_RS22085 (L2Y90_22035)	1037315..1038943	-	1629	WP_258284643.1	methyl-accepting chemotaxis protein	-
L2Y90_RS22090 (L2Y90_22040)	1039292..1039735	+	444	WP_258284644.1	PaaI family thioesterase	-
L2Y90_RS22095 (L2Y90_22045)	1039813..1040094	-	282	WP_258284645.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L2Y90_RS22100 (L2Y90_22050)	1040084..1040332	-	249	WP_047902230.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
L2Y90_RS22105 (L2Y90_22055)	1040451..1041503	-	1053	WP_258284646.1	CaiB/BaiF CoA-transferase family protein	-
L2Y90_RS22110 (L2Y90_22060)	1041715..1042479	-	765	WP_034181637.1	helix-turn-helix domain-containing protein	-
L2Y90_RS22115 (L2Y90_22065)	1042615..1043397	+	783	WP_258284647.1	crotonase/enoyl-CoA hydratase family protein	-
L2Y90_RS22120 (L2Y90_22070)	1043480..1044700	+	1221	WP_034181635.1	CoA transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10937.86 Da
• Isoelectric Point: 10.7091

>T233111 WP_258284645.1 NZ_CP091308:c1040094-1039813 [Burkholderia pyrrocinia]
MTFELAFLEAALKEWKKLDRTVRDQFKARLAERLENPRIPSAKLHGHPDRYKIKLRSVGYRLVYEVREAEVVVLVVAVGR
RERDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T233111 NZ_CP128530:c2158128-2157739 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGCGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8935.26 Da
• Isoelectric Point: 5.0636

>AT233111 WP_047902230.1 NZ_CP091308:c1040332-1040084 [Burkholderia pyrrocinia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRAKEKAVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT233111 NZ_CP128530:c2158389-2158129 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAACAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G3WYJ8