Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 386071..387289 Replicon chromosome
Accession NZ_CP091308
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Y90_RS19165 Protein ID WP_258284205.1
Coordinates 386708..387289 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Y90_RS19160 Protein ID WP_258284204.1
Coordinates 386071..386628 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS19135 (L2Y90_19085) 381691..381852 + 162 WP_258284199.1 hypothetical protein -
L2Y90_RS19140 (L2Y90_19090) 381925..382656 - 732 WP_258284200.1 ribonuclease T2 -
L2Y90_RS19145 (L2Y90_19095) 382909..383487 - 579 WP_258284201.1 hypothetical protein -
L2Y90_RS19150 (L2Y90_19100) 383581..384984 - 1404 WP_258284202.1 DUF308 domain-containing protein -
L2Y90_RS19155 (L2Y90_19105) 385348..385986 + 639 WP_258284203.1 hypothetical protein -
L2Y90_RS19160 (L2Y90_19110) 386071..386628 + 558 WP_258284204.1 helix-turn-helix transcriptional regulator Antitoxin
L2Y90_RS19165 (L2Y90_19115) 386708..387289 + 582 WP_258284205.1 HD domain-containing protein Toxin
L2Y90_RS19170 (L2Y90_19120) 387574..388767 + 1194 WP_258284206.1 efflux RND transporter periplasmic adaptor subunit -
L2Y90_RS19175 (L2Y90_19125) 388770..390854 + 2085 WP_258284207.1 MacB family efflux pump subunit -
L2Y90_RS19180 (L2Y90_19130) 390868..392241 + 1374 WP_258284208.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21306.77 Da        Isoelectric Point: 4.9532

>T233110 WP_258284205.1 NZ_CP091308:386708-387289 [Burkholderia pyrrocinia]
MNPDTIHARLDFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLTALVFADALPGIDTQKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDAGGQRA

Download         Length: 582 bp

>T233110 NZ_CP128530:1570909-1571214 [Mannheimia haemolytica]
ATGTTTAACTTAACCGAAGCCCATTTTAGAGATGAAGCTCTTTATCGGTTCTTCCAATATGGCGAAGTCAGCAGAACAAT
CCCTGCTAATCTCACAAGCGTATTAGCTCGCAAACTGGATATGATTAATGCAGCTGAAAAGCTGAATGACTTACGCAGTC
CGCCTGCTAATCGCTTAGAGTTACTTGAGCCGAAACAGAACAACGTCTATTCAATTCGAGTAAACAAACAGTATCGATTG
ATTTTCAAGTTTGAAAACAATGAACTCTCTGATTTATACCTTGACCCACACAATTACGACCTATAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20125.01 Da        Isoelectric Point: 10.1931

>AT233110 WP_258284204.1 NZ_CP091308:386071-386628 [Burkholderia pyrrocinia]
MTASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARTAEFSQPLSMLLGASLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT233110 NZ_CP128530:1571226-1571546 [Mannheimia haemolytica]
ATGATGCAACGCAAACCGACCCCGGTTGGGGAAATTCTCCAGGAAGAATTTTTAGCGCCACTTAATCTTAAAATCGGCGA
CCTCGTTGAAATTTTAGACGTACACCGCAACACCGCCAGCAACCTTGTGAATAACAGTTGCCGTGTTAGTCCTGAAATGG
CATTTAAATTGGCAAAAGCCTTTGATACCAGCCCTGAATTTTGGCTCAACCTACAAACCGCAACCGATTTATGGGAACTC
CGCCATAACAACCGCTTCCAACAAAGCCTTGATAGCGTAAAAGCCGTAAATCACTGGCAAGGTGTGCCTGCATTTGCTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References