Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2623727..2624346 Replicon chromosome
Accession NC_011740
Organism Escherichia fergusonii ATCC 35469

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EFER_RS12890 Protein ID WP_001280991.1
Coordinates 2624128..2624346 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag EFER_RS12885 Protein ID WP_000344803.1
Coordinates 2623727..2624101 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EFER_RS12875 2618859..2620052 + 1194 WP_015953614.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EFER_RS12880 2620075..2623224 + 3150 WP_001132491.1 efflux RND transporter permease AcrB -
EFER_RS12885 2623727..2624101 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
EFER_RS12890 2624128..2624346 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
EFER_RS12895 2624843..2625313 + 471 WP_002431406.1 YlaC family protein -
EFER_RS12900 2625452..2627002 + 1551 WP_001260376.1 EAL domain-containing protein -
EFER_RS12905 2627044..2627397 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EFER_RS12910 2627776..2628087 + 312 WP_000409911.1 MGMT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2628188..2629516 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T23311 WP_001280991.1 NC_011740:2624128-2624346 [Escherichia fergusonii ATCC 35469]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T23311 NC_011740:2624128-2624346 [Escherichia fergusonii ATCC 35469]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT23311 WP_000344803.1 NC_011740:2623727-2624101 [Escherichia fergusonii ATCC 35469]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT23311 NC_011740:2623727-2624101 [Escherichia fergusonii ATCC 35469]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References