Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 299895..300424 Replicon chromosome
Accession NZ_CP091308
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag L2Y90_RS18745 Protein ID WP_258284147.1
Coordinates 300158..300424 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag L2Y90_RS18740 Protein ID WP_258284146.1
Coordinates 299895..300161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS18710 (L2Y90_18665) 295246..296454 - 1209 WP_258284143.1 acetate/propionate family kinase -
L2Y90_RS18715 (L2Y90_18670) 296465..297436 - 972 WP_258284144.1 phosphate acetyltransferase -
L2Y90_RS18720 (L2Y90_18675) 297583..298452 + 870 WP_258284145.1 ATP synthase F1 subunit gamma -
L2Y90_RS18725 (L2Y90_18680) 298464..298922 + 459 WP_152856885.1 ATP synthase F1 subunit epsilon -
L2Y90_RS18730 (L2Y90_18685) 298952..299170 - 219 WP_006480837.1 DUF1653 domain-containing protein -
L2Y90_RS18735 (L2Y90_18690) 299228..299671 - 444 WP_048245578.1 GNAT family N-acetyltransferase -
L2Y90_RS18740 (L2Y90_18695) 299895..300161 + 267 WP_258284146.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L2Y90_RS18745 (L2Y90_18700) 300158..300424 + 267 WP_258284147.1 Txe/YoeB family addiction module toxin Toxin
L2Y90_RS18750 (L2Y90_18705) 300733..301356 + 624 WP_258284148.1 HAD hydrolase-like protein -
L2Y90_RS18755 (L2Y90_18710) 301747..302325 + 579 WP_174419371.1 DUF4142 domain-containing protein -
L2Y90_RS18760 (L2Y90_18715) 302496..303095 - 600 WP_258284149.1 GNAT family protein -
L2Y90_RS18765 (L2Y90_18720) 303152..304066 - 915 WP_175947719.1 LysR family transcriptional regulator -
L2Y90_RS18770 (L2Y90_18725) 304176..305414 + 1239 WP_258284150.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10474.83 Da        Isoelectric Point: 9.4571

>T233109 WP_258284147.1 NZ_CP091308:300158-300424 [Burkholderia pyrrocinia]
MSVRRVLVTSDARDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKARLSGFWSRRIDDTNRPVYEADDLQISI
VSCRYHYE

Download         Length: 267 bp

>T233109 NZ_CP128530:1383793-1383969 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9930.23 Da        Isoelectric Point: 6.4824

>AT233109 WP_258284146.1 NZ_CP091308:299895-300161 [Burkholderia pyrrocinia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKGKAKE
HKLAEDDE

Download         Length: 267 bp

>AT233109 NZ_CP128530:1384025-1384441 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References