Detailed information of TA system TA233106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1695008..1695654
• Replicon: chromosome
• Accession: NZ_CP091307
• Organism: Burkholderia pyrrocinia strain LWK2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L2Y90_RS07885
• Protein ID: WP_258282760.1
• Coordinates: 1695008..1695418 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A2S8IZ81
• Locus tag: L2Y90_RS07890
• Protein ID: WP_034183867.1
• Coordinates: 1695418..1695654 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Y90_RS07875 (L2Y90_07865)	1692393..1693529	+	1137	WP_258282759.1	alginate lyase family protein	-
L2Y90_RS07880 (L2Y90_07870)	1693561..1694949	+	1389	WP_152862443.1	L-serine ammonia-lyase	-
L2Y90_RS07885 (L2Y90_07875)	1695008..1695418	-	411	WP_258282760.1	type II toxin-antitoxin system VapC family toxin	Toxin
L2Y90_RS07890 (L2Y90_07880)	1695418..1695654	-	237	WP_034183867.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L2Y90_RS07895 (L2Y90_07885)	1695905..1696213	-	309	WP_258282761.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L2Y90_RS07900 (L2Y90_07890)	1696210..1696671	-	462	WP_131948726.1	hypothetical protein	-
L2Y90_RS07905 (L2Y90_07895)	1696978..1698681	+	1704	WP_258282762.1	thiamine pyrophosphate-binding protein	-
L2Y90_RS07910 (L2Y90_07900)	1698678..1699772	+	1095	WP_258282763.1	ADP-heptose--LPS heptosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15328.50 Da
• Isoelectric Point: 4.7351

>T233106 WP_258282760.1 NZ_CP091307:c1695418-1695008 [Burkholderia pyrrocinia]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAVTYAELEYGVAVCANPDRERLNLSALIEDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVALVTNNERDFVSYPGLRMENWLNDSCP

Nucleotide

• Length: 411 bp

>T233106 NZ_CP128530:c253671-253339 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9089.26 Da
• Isoelectric Point: 5.8835

>AT233106 WP_034183867.1 NZ_CP091307:c1695654-1695418 [Burkholderia pyrrocinia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTRVLEKFAKFGPDFMSEGRGDQEQAEREGL

Nucleotide

• Length: 237 bp

>AT233106 NZ_CP128530:c253928-253668 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCATGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S8IZ81