233105

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 28124..28800 Replicon chromosome
Accession NZ_CP091307
Organism Burkholderia pyrrocinia strain LWK2

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag L2Y90_RS00135 Protein ID WP_105390195.1
Coordinates 28124..28540 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag L2Y90_RS00140 Protein ID WP_258281861.1
Coordinates 28537..28800 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y90_RS00110 (L2Y90_00110) 23520..23765 - 246 WP_034184154.1 type II toxin-antitoxin system ParD family antitoxin -
L2Y90_RS00115 (L2Y90_00115) 23903..24442 - 540 WP_258281857.1 outer membrane protein assembly factor BamE -
L2Y90_RS00120 (L2Y90_00120) 24621..25784 - 1164 WP_258281858.1 M20 aminoacylase family protein -
L2Y90_RS00125 (L2Y90_00125) 26128..27201 + 1074 WP_258281859.1 type IV toxin-antitoxin system AbiEi family antitoxin -
L2Y90_RS00130 (L2Y90_00130) 27170..28075 + 906 WP_258281860.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L2Y90_RS00135 (L2Y90_00135) 28124..28540 - 417 WP_105390195.1 PIN domain-containing protein Toxin
L2Y90_RS00140 (L2Y90_00140) 28537..28800 - 264 WP_258281861.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L2Y90_RS00145 (L2Y90_00145) 29051..30064 - 1014 WP_258281862.1 GNAT family N-acetyltransferase -
L2Y90_RS00150 (L2Y90_00150) 30064..30903 - 840 WP_258281863.1 formyltransferase family protein -
L2Y90_RS00155 (L2Y90_00155) 30990..33311 - 2322 WP_258281864.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14594.80 Da        Isoelectric Point: 7.8895

>T233105 WP_105390195.1 NZ_CP091307:c28540-28124 [Burkholderia pyrrocinia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVVGLSLEDWAA

Download         Length: 417 bp

>T233105 NZ_CP128530:c22031-21603 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9761.03 Da        Isoelectric Point: 4.6561

>AT233105 WP_258281861.1 NZ_CP091307:c28800-28537 [Burkholderia pyrrocinia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADAEFLAERPAVIESGRFDLSGDTG
APTESGR

Download         Length: 264 bp

>AT233105 NZ_CP128530:c22318-22031 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References