Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 13345..13864 Replicon plasmid pUK043_3
Accession NZ_CP091304
Organism Enterococcus faecium strain UK043

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag L3K57_RS15285 Protein ID WP_000588503.1
Coordinates 13607..13864 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag L3K57_RS15280 Protein ID WP_000388479.1
Coordinates 13345..13614 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3K57_RS15230 (L3K57_15230) 8542..9441 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
L3K57_RS15235 (L3K57_15235) 9444..9929 + 486 WP_002303313.1 single-stranded DNA-binding protein -
L3K57_RS15240 (L3K57_15240) 10070..10174 - 105 WP_008274030.1 putative holin-like toxin -
L3K57_RS15245 (L3K57_15245) 10348..10608 + 261 WP_002295623.1 hypothetical protein -
L3K57_RS15250 (L3K57_15250) 11045..11251 + 207 WP_002347218.1 hypothetical protein -
L3K57_RS15255 (L3K57_15255) 11251..11502 + 252 WP_002296238.1 hypothetical protein -
L3K57_RS15260 (L3K57_15260) 11517..11954 + 438 WP_002300851.1 hypothetical protein -
L3K57_RS15265 (L3K57_15265) 11947..12654 + 708 WP_002303117.1 hypothetical protein -
L3K57_RS15270 (L3K57_15270) 12819..13019 + 201 WP_002347143.1 hypothetical protein -
L3K57_RS15275 (L3K57_15275) 13035..13214 + 180 WP_001120991.1 hypothetical protein -
L3K57_RS15280 (L3K57_15280) 13345..13614 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3K57_RS15285 (L3K57_15285) 13607..13864 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
L3K57_RS15290 (L3K57_15290) 14323..14478 + 156 WP_002347142.1 hypothetical protein -
L3K57_RS15295 (L3K57_15295) 14502..15326 + 825 WP_001809248.1 hypothetical protein -
L3K57_RS15300 (L3K57_15300) 15491..16105 - 615 WP_001261742.1 recombinase family protein -
L3K57_RS15305 (L3K57_15305) 16343..16765 + 423 WP_002303116.1 hypothetical protein -
L3K57_RS15310 (L3K57_15310) 16775..17116 + 342 WP_236918139.1 hypothetical protein -
L3K57_RS15315 (L3K57_15315) 17188..17772 + 585 WP_002299575.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60386 60386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T233104 WP_000588503.1 NZ_CP091304:13607-13864 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T233104 NZ_CP128529:2095580-2095912 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT233104 WP_000388479.1 NZ_CP091304:13345-13614 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT233104 NZ_CP128529:2095323-2095583 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References