Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2164339..2164868 Replicon chromosome
Accession NZ_CP091301
Organism Enterococcus faecium strain UK043

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag L3K57_RS10810 Protein ID WP_002296560.1
Coordinates 2164602..2164868 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag L3K57_RS10805 Protein ID WP_002296559.1
Coordinates 2164339..2164602 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L3K57_RS10795 (L3K57_10795) 2161713..2163536 + 1824 WP_002294202.1 APC family permease -
L3K57_RS10800 (L3K57_10800) 2163678..2163863 - 186 WP_002296558.1 transcriptional regulator -
L3K57_RS10805 (L3K57_10805) 2164339..2164602 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L3K57_RS10810 (L3K57_10810) 2164602..2164868 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
L3K57_RS10815 (L3K57_10815) 2165069..2165557 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
L3K57_RS10820 (L3K57_10820) 2166098..2166769 - 672 WP_002302663.1 ABC transporter permease -
L3K57_RS10825 (L3K57_10825) 2166766..2167683 - 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
L3K57_RS10830 (L3K57_10830) 2167680..2168321 - 642 WP_002293405.1 ABC transporter permease -
L3K57_RS10835 (L3K57_10835) 2168325..2169502 - 1178 Protein_2080 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T233098 WP_002296560.1 NZ_CP091301:2164602-2164868 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T233098 NZ_CP128529:470634-470930 [Mannheimia haemolytica]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT233098 WP_002296559.1 NZ_CP091301:2164339-2164602 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT233098 NZ_CP128529:470914-471156 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References