Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3870371..3871185 | Replicon | chromosome |
| Accession | NZ_CP091300 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | M7RPS8 |
| Locus tag | L1971_RS19460 | Protein ID | WP_000971649.1 |
| Coordinates | 3870371..3870898 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | L1971_RS19465 | Protein ID | WP_000855694.1 |
| Coordinates | 3870895..3871185 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1971_RS19430 (3866581) | 3866581..3866979 | + | 399 | Protein_3657 | cytoplasmic protein | - |
| L1971_RS19435 (3867170) | 3867170..3867409 | + | 240 | Protein_3658 | hypothetical protein | - |
| L1971_RS19440 (3867566) | 3867566..3868234 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| L1971_RS19445 (3868261) | 3868261..3868755 | + | 495 | WP_000424942.1 | hypothetical protein | - |
| L1971_RS19450 (3869000) | 3869000..3869656 | - | 657 | WP_024799050.1 | protein-serine/threonine phosphatase | - |
| L1971_RS19455 (3869889) | 3869889..3870298 | + | 410 | Protein_3662 | IS5/IS1182 family transposase | - |
| L1971_RS19460 (3870371) | 3870371..3870898 | - | 528 | WP_000971649.1 | GNAT family N-acetyltransferase | Toxin |
| L1971_RS19465 (3870895) | 3870895..3871185 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| L1971_RS19470 (3871455) | 3871455..3871633 | - | 179 | Protein_3665 | IS3 family transposase | - |
| L1971_RS19475 (3871874) | 3871874..3872200 | + | 327 | WP_000393300.1 | hypothetical protein | - |
| L1971_RS19480 (3872473) | 3872473..3872820 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| L1971_RS19485 (3872805) | 3872805..3873254 | - | 450 | WP_000381612.1 | membrane protein | - |
| L1971_RS19490 (3873686) | 3873686..3874129 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| L1971_RS19495 (3874585) | 3874585..3875235 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 3869000..3880548 | 11548 | |
| - | flank | IS/Tn | - | - | 3870158..3870298 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19026.88 Da Isoelectric Point: 9.3905
>T233097 WP_000971649.1 NZ_CP091300:c3870898-3870371 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T233097 NZ_CP128529:177888-178277 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT233097 WP_000855694.1 NZ_CP091300:c3871185-3870895 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT233097 NZ_CP128529:177627-177887 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V5VVF5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |