Detailed information of TA system TA233096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3716231..3716856
• Replicon: chromosome
• Accession: NZ_CP091300
• Organism: Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L1971_RS18770
• Protein ID: WP_000911337.1
• Coordinates: 3716458..3716856 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: L1971_RS18765
• Protein ID: WP_000557545.1
• Coordinates: 3716231..3716458 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1971_RS18735 (3711327)	3711327..3712425	+	1099	WP_096059418.1	peptide chain release factor 2	-
L1971_RS18740 (3712435)	3712435..3713952	+	1518	WP_000003339.1	lysine--tRNA ligase	-
L1971_RS18745 (3714028)	3714028..3714573	-	546	WP_021000753.1	isopentenyl-diphosphate Delta-isomerase	-
L1971_RS18750 (3714838)	3714838..3715596	+	759	WP_000244328.1	amidase activator ActS	-
L1971_RS18760 (3715842)	3715842..3716054	-	213	WP_024133381.1	hypothetical protein	-
L1971_RS18765 (3716231)	3716231..3716458	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
L1971_RS18770 (3716458)	3716458..3716856	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
L1971_RS18775 (3717663)	3717663..3718199	+	537	WP_001038500.1	STM3031 family outer membrane protein	-
L1971_RS18780 (3718246)	3718246..3718878	+	633	WP_000835265.1	YfdX family protein	-
L1971_RS18785 (3719597)	3719597..3720181	+	585	WP_021000750.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3716231..3726049	9818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T233096 WP_000911337.1 NZ_CP091300:3716458-3716856 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T233096 NZ_CP128529:c25018-24590 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT233096 WP_000557545.1 NZ_CP091300:3716231-3716458 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT233096 NZ_CP128529:c25305-25018 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6