Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3706503..3707163 Replicon chromosome
Accession NZ_CP091300
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L1971_RS18710 Protein ID WP_000244756.1
Coordinates 3706750..3707163 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L1971_RS18705 Protein ID WP_000351186.1
Coordinates 3706503..3706769 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1971_RS18685 (3702431) 3702431..3703864 - 1434 WP_024799149.1 6-phospho-beta-glucosidase BglA -
L1971_RS18690 (3704023) 3704023..3704334 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L1971_RS18695 (3704498) 3704498..3705157 + 660 WP_000250289.1 hemolysin III family protein -
L1971_RS18700 (3705273) 3705273..3706253 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
L1971_RS18705 (3706503) 3706503..3706769 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L1971_RS18710 (3706750) 3706750..3707163 + 414 WP_000244756.1 protein YgfX Toxin
L1971_RS18715 (3707216) 3707216..3707737 - 522 WP_001055885.1 flavodoxin FldB -
L1971_RS18720 (3707850) 3707850..3708746 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L1971_RS18725 (3708770) 3708770..3709483 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L1971_RS18730 (3709489) 3709489..3711222 + 1734 WP_000813385.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T233095 WP_000244756.1 NZ_CP091300:3706750-3707163 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T233095 NZ_CP128528:2190362-2190694 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT233095 WP_000351186.1 NZ_CP091300:3706503-3706769 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT233095 NZ_CP128528:2190105-2190365 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References