Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3083931..3084691 Replicon chromosome
Accession NZ_CP091300
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L1971_RS15690 Protein ID WP_000533909.1
Coordinates 3084206..3084691 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag L1971_RS15685 Protein ID WP_000965886.1
Coordinates 3083931..3084218 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1971_RS15670 (3079554) 3079554..3081623 + 2070 WP_021000891.1 glycine--tRNA ligase subunit beta -
L1971_RS15675 (3081885) 3081885..3082286 + 402 Protein_2923 IS3 family transposase -
L1971_RS15680 (3082680) 3082680..3083585 + 906 WP_021000890.1 hypothetical protein -
L1971_RS15685 (3083931) 3083931..3084218 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
L1971_RS15690 (3084206) 3084206..3084691 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L1971_RS15695 (3085063) 3085063..3085602 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
L1971_RS15700 (3085777) 3085777..3085989 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L1971_RS15705 (3086277) 3086277..3086567 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L1971_RS15710 (3087006) 3087006..3087716 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L1971_RS15715 (3087766) 3087766..3088740 - 975 WP_021000888.1 glyoxylate/hydroxypyruvate reductase GhrB -
L1971_RS15720 (3088959) 3088959..3089621 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233093 WP_000533909.1 NZ_CP091300:3084206-3084691 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233093 NZ_CP128528:1636705-1636929 [Mannheimia haemolytica]
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACACTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCGAATCCTGATACAGATAAGGGGCGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233093 WP_000965886.1 NZ_CP091300:3083931-3084218 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233093 NZ_CP128528:1636972-1637301 [Mannheimia haemolytica]
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTCATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGTGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References