Detailed information of TA system TA233088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 551287..551809
• Replicon: chromosome
• Accession: NZ_CP091300
• Organism: Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: V7IL40
• Locus tag: L1971_RS03540
• Protein ID: WP_000221345.1
• Coordinates: 551525..551809 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: L1971_RS03535
• Protein ID: WP_000885424.1
• Coordinates: 551287..551535 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1971_RS03510 (546588)	546588..548054	+	1467	WP_021000344.1	hypothetical protein	-
L1971_RS03515 (548887)	548887..549483	+	597	Protein_558	helix-turn-helix domain-containing protein	-
L1971_RS03520 (549539)	549539..550447	-	909	WP_077914398.1	hypothetical protein	-
L1971_RS03525 (550598)	550598..550930	-	333	WP_021000342.1	DUF1493 family protein	-
L1971_RS03530 (550920)	550920..551135	-	216	WP_000206207.1	hypothetical protein	-
L1971_RS03535 (551287)	551287..551535	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L1971_RS03540 (551525)	551525..551809	+	285	WP_000221345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L1971_RS03545 (551980)	551980..552369	+	390	WP_012218813.1	RidA family protein	-
L1971_RS03550 (552421)	552421..553500	-	1080	WP_001618066.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
L1971_RS03555 (553693)	553693..554181	-	489	WP_021000341.1	MarR family winged helix-turn-helix transcriptional regulator	-
L1971_RS03560 (554226)	554226..555734	+	1509	WP_021000340.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	546591..558591	12000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.79 Da
• Isoelectric Point: 10.6500

>T233088 WP_000221345.1 NZ_CP091300:551525-551809 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Nucleotide

• Length: 285 bp

>T233088 NZ_CP128528:272782-273171 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT233088 WP_000885424.1 NZ_CP091300:551287-551535 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT233088 NZ_CP128528:272521-272781 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A5Y2FFA8

Antitoxin

• AlphaFold DB: A0A5I0WPN5