Detailed information of TA system TA233079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 66346..66971
• Replicon: plasmid pSCD1
• Accession: NZ_CP091299
• Organism: Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L1971_RS00410
• Protein ID: WP_000911323.1
• Coordinates: 66346..66744 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: L1971_RS00415
• Protein ID: WP_000450263.1
• Coordinates: 66744..66971 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1971_RS00390 (L1971_00390)	61960..62271	-	312	WP_000522257.1	hypothetical protein	-
L1971_RS00395 (L1971_00395)	62370..63101	+	732	WP_000782437.1	conjugal transfer complement resistance protein TraT	-
L1971_RS00400 (L1971_00400)	63353..63832	+	480	WP_025649166.1	hypothetical protein	-
L1971_RS00405 (L1971_00405)	64112..66337	+	2226	WP_152280056.1	type IV conjugative transfer system coupling protein TraD	-
L1971_RS00410 (L1971_00410)	66346..66744	-	399	WP_000911323.1	tRNA(fMet)-specific endonuclease VapC	Toxin
L1971_RS00415 (L1971_00415)	66744..66971	-	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	fdeC / spvC / spvB / rck / pefD / pefC / pefA / pefB	1..104427	104427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14885.16 Da
• Isoelectric Point: 9.2199

>T233079 WP_000911323.1 NZ_CP091299:c66744-66346 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSRMPERNLAVIEGFVSRLDVLDYDAPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T233079 NZ_CP128527:c25018-24590 [Mannheimia haemolytica]
ATGTATCGCTACCTTTTTGATACCAATATAGTTTCCGAGCTTTATAAGTTAAGAAATGACAAGATGGATGTCAATGTTCG
CCAGTGGCTGAGAGGGGTTAATCCTAGCCAGACCAATATCAGCTGTATTACGTTATCTGAAATCAAAACAGGTATTTTGC
TGAAAGCCCGCAAAGACAAAGAACAATCAGACCGATTAAATGATTGGTTTGAAAATAATGTATTAAAGGCTTATCAAACA
AAAGCGTTTGTGGTGAATAACGACATTGCTCTATTGGCATCAGAGTACCATATTCCCAATAAAATGGATTTAAATGATGC
TTATATTGCGGCAACCGCCAAATACCACAATCTGATTTTAGTCACCCGCAACACCAAAGATTTTATCCGTTGTGATGTGC
GTTTATTTAACCCATTTGAAACCGCATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8532.53 Da
• Isoelectric Point: 4.7513

>AT233079 WP_000450263.1 NZ_CP091299:c66971-66744 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
METSVFLSNRSQAVRLPKAVALPEHVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT233079 NZ_CP128527:c25305-25018 [Mannheimia haemolytica]
ATGGCAATAACCATTACTTCCAGAGAATTTAATCAAAATGCCAGCAAAGTGTTAAAAATGGCAGAAAAAGAGCCGGTTTT
TATTACCAAATGGGGCAAAATCGTCAATGTGGTGTCTAGTTATATGGATTATCAGCAGAAAAAGCCTAGCGAGCCAAGCT
TTGAAGAGCTATTCGCCTCTTCCGAAAATGAGGATGTGAGCGATGAATTTTGGCAAGAGTTTGAACAAACATTGGTTGAA
ATCCGCAAAAGCAATAAACCAAGACCTGTTGATTTTGGAGATGAGTAA