Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 6356..6881 | Replicon | plasmid pSCD1 |
| Accession | NZ_CP091299 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | L1971_RS00045 | Protein ID | WP_001159863.1 |
| Coordinates | 6576..6881 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | L1971_RS00040 | Protein ID | WP_000813641.1 |
| Coordinates | 6356..6574 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1971_RS00020 (L1971_00020) | 2868..3956 | - | 1089 | WP_021003379.1 | transcriptional repressor PifC | - |
| L1971_RS00025 (L1971_00025) | 4194..4937 | - | 744 | WP_001292424.1 | hypothetical protein | - |
| L1971_RS00030 (L1971_00030) | 4969..5385 | - | 417 | WP_001697179.1 | type II toxin-antitoxin system VapC family toxin | - |
| L1971_RS00035 (L1971_00035) | 5382..5612 | - | 231 | WP_001261289.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| L1971_RS00040 (L1971_00040) | 6356..6574 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| L1971_RS00045 (L1971_00045) | 6576..6881 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| L1971_RS00050 (L1971_00050) | 6883..7173 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| L1971_RS00055 (L1971_00055) | 7170..7691 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| L1971_RS00060 (L1971_00060) | 7726..8508 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| L1971_RS00065 (L1971_00065) | 8517..9230 | + | 714 | WP_237123644.1 | EAL domain-containing protein | - |
| L1971_RS00070 (L1971_00070) | 9255..9743 | + | 489 | WP_237123648.1 | CaiF/GrlA family transcriptional regulator | - |
| L1971_RS00075 (L1971_00075) | 9737..10222 | + | 486 | WP_000905606.1 | membrane protein | - |
| L1971_RS00080 (L1971_00080) | 10499..10786 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| L1971_RS00085 (L1971_00085) | 10942..11502 | + | 561 | WP_071991890.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | fdeC / spvC / spvB / rck / pefD / pefC / pefA / pefB | 1..104427 | 104427 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T233078 WP_001159863.1 NZ_CP091299:6576-6881 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T233078 NZ_CP128526:2312249-2312581 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT233078 WP_000813641.1 NZ_CP091299:6356-6574 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT233078 NZ_CP128526:2311992-2312252 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |