Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1031844..1032481 | Replicon | chromosome |
| Accession | NZ_CP091288 | ||
| Organism | Bacillus velezensis strain JJ47 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | L3C11_RS05205 | Protein ID | WP_003156187.1 |
| Coordinates | 1031844..1032194 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | I2HMS5 |
| Locus tag | L3C11_RS05210 | Protein ID | WP_003156188.1 |
| Coordinates | 1032200..1032481 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3C11_RS05165 (L3C11_05165) | 1026884..1027486 | - | 603 | WP_007410234.1 | PP2C family serine/threonine-protein phosphatase | - |
| L3C11_RS05170 (L3C11_05170) | 1027486..1028274 | - | 789 | WP_032873003.1 | RNA polymerase sigma factor SigB | - |
| L3C11_RS05175 (L3C11_05175) | 1028240..1028722 | - | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
| L3C11_RS05180 (L3C11_05180) | 1028719..1029048 | - | 330 | WP_003156176.1 | anti-sigma factor antagonist RsbV | - |
| L3C11_RS05185 (L3C11_05185) | 1029112..1030119 | - | 1008 | WP_007609589.1 | PP2C family protein-serine/threonine phosphatase | - |
| L3C11_RS05190 (L3C11_05190) | 1030131..1030532 | - | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
| L3C11_RS05195 (L3C11_05195) | 1030535..1030900 | - | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
| L3C11_RS05200 (L3C11_05200) | 1030905..1031726 | - | 822 | WP_003156182.1 | STAS domain-containing protein | - |
| L3C11_RS05205 (L3C11_05205) | 1031844..1032194 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| L3C11_RS05210 (L3C11_05210) | 1032200..1032481 | - | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| L3C11_RS05215 (L3C11_05215) | 1032601..1033770 | - | 1170 | WP_032873001.1 | alanine racemase | - |
| L3C11_RS05220 (L3C11_05220) | 1033887..1034894 | - | 1008 | WP_032872999.1 | outer membrane lipoprotein carrier protein LolA | - |
| L3C11_RS05225 (L3C11_05225) | 1035059..1035424 | - | 366 | WP_007609580.1 | holo-ACP synthase | - |
| L3C11_RS05230 (L3C11_05230) | 1035517..1036116 | + | 600 | WP_032872997.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T233072 WP_003156187.1 NZ_CP091288:c1032194-1031844 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T233072 NZ_CP128526:564259-564555 [Mannheimia haemolytica]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT233072 WP_003156188.1 NZ_CP091288:c1032481-1032200 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT233072 NZ_CP128526:564539-564781 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|