Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1201030..1201517 Replicon chromosome
Accession NZ_CP091281
Organism Macrococcus canis strain B8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L2Z53_RS06140 Protein ID WP_261785718.1
Coordinates 1201251..1201517 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L2Z53_RS06135 Protein ID WP_236365521.1
Coordinates 1201030..1201254 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z53_RS06090 (L2Z53_06090) 1197087..1197557 + 471 WP_086042485.1 GNAT family N-acetyltransferase -
L2Z53_RS06095 (L2Z53_06095) 1197664..1198050 + 387 WP_086042486.1 sporulation protein -
L2Z53_RS06100 (L2Z53_06100) 1198113..1198628 - 516 WP_086042487.1 DUF402 domain-containing protein -
L2Z53_RS06105 (L2Z53_06105) 1198721..1199179 + 459 WP_086042488.1 NUDIX domain-containing protein -
L2Z53_RS06110 (L2Z53_06110) 1199275..1199526 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L2Z53_RS06115 (L2Z53_06115) 1199526..1199786 + 261 WP_236365518.1 Txe/YoeB family addiction module toxin -
L2Z53_RS06120 (L2Z53_06120) 1199779..1200195 + 417 WP_236365519.1 hypothetical protein -
L2Z53_RS06125 (L2Z53_06125) 1200218..1200490 - 273 WP_236365520.1 Txe/YoeB family addiction module toxin -
L2Z53_RS06130 (L2Z53_06130) 1200483..1200740 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
L2Z53_RS06135 (L2Z53_06135) 1201030..1201254 + 225 WP_236365521.1 DUF6290 family protein Antitoxin
L2Z53_RS06140 (L2Z53_06140) 1201251..1201517 + 267 WP_261785718.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Z53_RS06145 (L2Z53_06145) 1201628..1201996 + 369 WP_236365523.1 GntR family transcriptional regulator -
L2Z53_RS06150 (L2Z53_06150) 1201996..1203096 + 1101 WP_236365524.1 DUF1648 domain-containing protein -
L2Z53_RS06155 (L2Z53_06155) 1203539..1204801 + 1263 WP_236366941.1 Y-family DNA polymerase -
L2Z53_RS06160 (L2Z53_06160) 1204954..1205142 + 189 WP_236365525.1 hypothetical protein -
L2Z53_RS06165 (L2Z53_06165) 1205275..1206315 + 1041 WP_236365526.1 M42 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10481.22 Da        Isoelectric Point: 10.4082

>T233069 WP_261785718.1 NZ_CP091281:1201251-1201517 [Macrococcus canis]
MKYSVEYDPKVIKQLRKLDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR

Download         Length: 267 bp

>T233069 NZ_CP128525:c2287263-2286874 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8745.91 Da        Isoelectric Point: 4.4193

>AT233069 WP_236365521.1 NZ_CP091281:1201030-1201254 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKHKQTVSHNDVMQEFGLL

Download         Length: 225 bp

>AT233069 NZ_CP128525:c2287524-2287264 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References