Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1201030..1201517 | Replicon | chromosome |
| Accession | NZ_CP091281 | ||
| Organism | Macrococcus canis strain B8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | L2Z53_RS06140 | Protein ID | WP_261785718.1 |
| Coordinates | 1201251..1201517 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | L2Z53_RS06135 | Protein ID | WP_236365521.1 |
| Coordinates | 1201030..1201254 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Z53_RS06090 (L2Z53_06090) | 1197087..1197557 | + | 471 | WP_086042485.1 | GNAT family N-acetyltransferase | - |
| L2Z53_RS06095 (L2Z53_06095) | 1197664..1198050 | + | 387 | WP_086042486.1 | sporulation protein | - |
| L2Z53_RS06100 (L2Z53_06100) | 1198113..1198628 | - | 516 | WP_086042487.1 | DUF402 domain-containing protein | - |
| L2Z53_RS06105 (L2Z53_06105) | 1198721..1199179 | + | 459 | WP_086042488.1 | NUDIX domain-containing protein | - |
| L2Z53_RS06110 (L2Z53_06110) | 1199275..1199526 | + | 252 | WP_086042489.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| L2Z53_RS06115 (L2Z53_06115) | 1199526..1199786 | + | 261 | WP_236365518.1 | Txe/YoeB family addiction module toxin | - |
| L2Z53_RS06120 (L2Z53_06120) | 1199779..1200195 | + | 417 | WP_236365519.1 | hypothetical protein | - |
| L2Z53_RS06125 (L2Z53_06125) | 1200218..1200490 | - | 273 | WP_236365520.1 | Txe/YoeB family addiction module toxin | - |
| L2Z53_RS06130 (L2Z53_06130) | 1200483..1200740 | - | 258 | WP_086042496.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| L2Z53_RS06135 (L2Z53_06135) | 1201030..1201254 | + | 225 | WP_236365521.1 | DUF6290 family protein | Antitoxin |
| L2Z53_RS06140 (L2Z53_06140) | 1201251..1201517 | + | 267 | WP_261785718.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2Z53_RS06145 (L2Z53_06145) | 1201628..1201996 | + | 369 | WP_236365523.1 | GntR family transcriptional regulator | - |
| L2Z53_RS06150 (L2Z53_06150) | 1201996..1203096 | + | 1101 | WP_236365524.1 | DUF1648 domain-containing protein | - |
| L2Z53_RS06155 (L2Z53_06155) | 1203539..1204801 | + | 1263 | WP_236366941.1 | Y-family DNA polymerase | - |
| L2Z53_RS06160 (L2Z53_06160) | 1204954..1205142 | + | 189 | WP_236365525.1 | hypothetical protein | - |
| L2Z53_RS06165 (L2Z53_06165) | 1205275..1206315 | + | 1041 | WP_236365526.1 | M42 family metallopeptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10481.22 Da Isoelectric Point: 10.4082
>T233069 WP_261785718.1 NZ_CP091281:1201251-1201517 [Macrococcus canis]
MKYSVEYDPKVIKQLRKLDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR
MKYSVEYDPKVIKQLRKLDAQSSRLLLQWINKNIVHCEDPRSSGKALTGNYSGFWRYRVGQFRIITKIEDDKLIILVISI
DHRKNIYR
Download Length: 267 bp
>T233069 NZ_CP128525:c2287263-2286874 [Mannheimia haemolytica]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8745.91 Da Isoelectric Point: 4.4193
>AT233069 WP_236365521.1 NZ_CP091281:1201030-1201254 [Macrococcus canis]
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKHKQTVSHNDVMQEFGLL
MATITIRVSEDEKNFLKYMSEFMNLSLTDLIKNYTIEDLEDLFDTHVADKAYIEWSKHKQTVSHNDVMQEFGLL
Download Length: 225 bp
>AT233069 NZ_CP128525:c2287524-2287264 [Mannheimia haemolytica]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|