Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3159580..3160176 Replicon chromosome
Accession NZ_CP091244
Organism Thiothrix winogradskyi strain CT3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L2Y54_RS15690 Protein ID WP_236497449.1
Coordinates 3159991..3160176 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L2Y54_RS15685 Protein ID WP_236497446.1
Coordinates 3159580..3159987 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y54_RS15660 (L2Y54_15665) 3155192..3155959 - 768 WP_236497438.1 hypothetical protein -
L2Y54_RS21720 3156320..3156451 - 132 WP_255697756.1 hypothetical protein -
L2Y54_RS15665 (L2Y54_15670) 3156462..3156746 - 285 WP_236497439.1 hypothetical protein -
L2Y54_RS15670 (L2Y54_15675) 3156727..3157638 - 912 WP_236497441.1 phage terminase small subunit -
L2Y54_RS15675 (L2Y54_15680) 3157641..3158690 - 1050 WP_236497442.1 phage major capsid protein, P2 family -
L2Y54_RS15680 (L2Y54_15685) 3159123..3159560 - 438 WP_236497444.1 DUF29 domain-containing protein -
L2Y54_RS15685 (L2Y54_15690) 3159580..3159987 - 408 WP_236497446.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Y54_RS15690 (L2Y54_15695) 3159991..3160176 - 186 WP_236497449.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Y54_RS15695 (L2Y54_15700) 3160284..3160826 - 543 WP_236497452.1 ProQ/FINO family protein -
L2Y54_RS15700 (L2Y54_15705) 3160842..3162110 - 1269 WP_236497453.1 tyrosine-type recombinase/integrase -
L2Y54_RS15705 (L2Y54_15710) 3162367..3163233 - 867 WP_236497455.1 PfkB family carbohydrate kinase -
L2Y54_RS15710 (L2Y54_15715) 3163320..3164264 + 945 WP_236497456.1 serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3151408..3184077 32669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6849.89 Da        Isoelectric Point: 10.9003

>T233066 WP_236497449.1 NZ_CP091244:c3160176-3159991 [Thiothrix winogradskyi]
MNSRELIKLLKAHGWELARTRGSHHQFKHPDHGHTVTVPHPKKDLGAGIVKAIKRQAGIED

Download         Length: 186 bp

>T233066 NZ_CP128525:c1250681-1250505 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14838.78 Da        Isoelectric Point: 4.7396

>AT233066 WP_236497446.1 NZ_CP091244:c3159987-3159580 [Thiothrix winogradskyi]
MYYPIAIEQGDANHAYGVIVPDIPGCFSAGDTLDEALMQAEDAILLQLEEYLDNGKPFPQPSPMEALRHQKAYEGFIWSI
TKVDVSKLSGKSTRVNISLPERILQLIDAAAERDGETRSGFIARAALGHIRQSAH

Download         Length: 408 bp

>AT233066 NZ_CP128525:c1250449-1250033 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References