Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2031739..2032796 Replicon chromosome
Accession NZ_CP091244
Organism Thiothrix winogradskyi strain CT3

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag L2Y54_RS10365 Protein ID WP_236501813.1
Coordinates 2032218..2032796 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag L2Y54_RS10360 Protein ID WP_236501812.1
Coordinates 2031739..2032218 (+) Length 160 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y54_RS10340 (L2Y54_10340) 2027898..2029109 - 1212 WP_236501807.1 hypothetical protein -
L2Y54_RS10345 (L2Y54_10345) 2029106..2029777 - 672 WP_236501808.1 type-F conjugative transfer system pilin assembly protein TrbC -
L2Y54_RS10350 (L2Y54_10350) 2029779..2030780 - 1002 WP_236501809.1 conjugal transfer pilus assembly protein TraU -
L2Y54_RS10355 (L2Y54_10355) 2030777..2031418 - 642 WP_236501810.1 type-F conjugative transfer system protein TraW -
L2Y54_RS10360 (L2Y54_10360) 2031739..2032218 + 480 WP_236501812.1 excisionase family DNA-binding protein Antitoxin
L2Y54_RS10365 (L2Y54_10365) 2032218..2032796 + 579 WP_236501813.1 PIN domain-containing protein Toxin
L2Y54_RS10370 (L2Y54_10370) 2032959..2035280 - 2322 WP_236501814.1 DEAD/DEAH box helicase -
L2Y54_RS10375 (L2Y54_10375) 2035386..2035904 - 519 WP_236501815.1 DNA repair protein RadC -
L2Y54_RS10380 (L2Y54_10380) 2035983..2037110 - 1128 WP_236501816.1 DUF6094 domain-containing protein -
L2Y54_RS10385 (L2Y54_10385) 2037211..2037411 - 201 WP_236501817.1 DUF2283 domain-containing protein -
L2Y54_RS10390 (L2Y54_10390) 2037490..2037699 + 210 WP_236501818.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-116)

Antitoxin

Helix-turn-helix domain, group 17

(89-137)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21936.23 Da        Isoelectric Point: 7.4360

>T233064 WP_236501813.1 NZ_CP091244:2032218-2032796 [Thiothrix winogradskyi]
MFSGTNFTALYDACVLYPAPLRDLLVRLAHTGTFRARWTQQIHEEWIRNALRNNPRLTRERLEATASKMNDAIMDSLVSD
YAPLIAGLELPDTNDRHVLAAAIKGQAEVIVTFNLKDFPDRCLHPFNIWAQHPDEFISHLIDLSPATVLLAARQQRAALK
NPPRTVDEFLDTLLRQQLPRTVAFLKERKDLI

Download         Length: 579 bp

>T233064 NZ_CP128525:c806863-806639 [Mannheimia haemolytica]
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACACTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCGAATCCTGATACAGATAAGGGGCGGTAG

Antitoxin


Download         Length: 160 a.a.        Molecular weight: 17967.80 Da        Isoelectric Point: 5.8413

>AT233064 WP_236501812.1 NZ_CP091244:2031739-2032218 [Thiothrix winogradskyi]
MRREQPKEFAAMSALISYQIPTSEDARLAVESSRLLATCIGKGESACLRLREGDEILQVPVKAIRLLVDILEAMARGDAV
SLIPIHKELTTQEAANLLNVSRPYLVKLLEKGDIPFHKNGVRRKVLFKDLMEYKQQRDQSTRELLDDLTAEAQELDMGY

Download         Length: 480 bp

>AT233064 NZ_CP128525:c806596-806267 [Mannheimia haemolytica]
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTCATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGTGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References