Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 763306..763982 Replicon chromosome
Accession NZ_CP091244
Organism Thiothrix winogradskyi strain CT3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2Y54_RS04040 Protein ID WP_236499977.1
Coordinates 763539..763982 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2Y54_RS04035 Protein ID WP_236499976.1
Coordinates 763306..763539 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y54_RS04020 (L2Y54_04020) 759308..759988 + 681 WP_236499970.1 rhodanese-like domain-containing protein -
L2Y54_RS04025 (L2Y54_04025) 760035..761867 - 1833 WP_236499972.1 ATP-binding protein -
L2Y54_RS04030 (L2Y54_04030) 761881..763080 - 1200 WP_236499974.1 FIST N-terminal domain-containing protein -
L2Y54_RS04035 (L2Y54_04035) 763306..763539 + 234 WP_236499976.1 DNA-binding protein Antitoxin
L2Y54_RS04040 (L2Y54_04040) 763539..763982 + 444 WP_236499977.1 type II toxin-antitoxin system VapC family toxin Toxin
L2Y54_RS04045 (L2Y54_04045) 763957..765588 - 1632 WP_236499980.1 NAD(P)-binding protein -
L2Y54_RS04050 (L2Y54_04050) 765585..766604 - 1020 WP_236499982.1 thiamine pyrophosphate-dependent enzyme -
L2Y54_RS04055 (L2Y54_04055) 766615..767868 - 1254 WP_236499984.1 transketolase C-terminal domain-containing protein -
L2Y54_RS04060 (L2Y54_04060) 767862..768443 - 582 WP_236499985.1 2-oxoacid:acceptor oxidoreductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16820.14 Da        Isoelectric Point: 6.0915

>T233062 WP_236499977.1 NZ_CP091244:763539-763982 [Thiothrix winogradskyi]
MYLLDTNVISELRKKERMNPGVARFVTQAQAQGSVCYLSVITLGELRRGIDLIYHRGDQEQATILERWLTTVLEEYSEQV
LDFGREEAQLWGHLRVPHPENALDKQIAATALIHDLILVTRNTKDFQSTRVKLYNPFDTTTSPPTPP

Download         Length: 444 bp

>T233062 NZ_CP128525:c253062-252730 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8764.18 Da        Isoelectric Point: 7.2045

>AT233062 WP_236499976.1 NZ_CP091244:763306-763539 [Thiothrix winogradskyi]
MANLIVRNISDEIAQALKMHASRMGISAEAAHRQILEQVLMRPKKKSFLELLKEMPNVGRDSDFERIQNDVAPEVFS

Download         Length: 234 bp

>AT233062 NZ_CP128525:c253319-253059 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References