Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 11205..12342 | Replicon | plasmid p705-a |
| Accession | NZ_CP091236 | ||
| Organism | Enterococcus faecalis strain 705 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LQ054_RS14075 | Protein ID | WP_077495093.1 |
| Coordinates | 11205..12068 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | A0A7U7LLF6 |
| Locus tag | LQ054_RS14080 | Protein ID | WP_031644662.1 |
| Coordinates | 12070..12342 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ054_RS14045 (LQ054_14045) | 6207..6887 | + | 681 | WP_013646119.1 | IS6-like element IS1216 family transposase | - |
| LQ054_RS14050 (LQ054_14050) | 6917..7021 | - | 105 | WP_224994000.1 | NAD(P)H-dependent oxidoreductase | - |
| LQ054_RS14055 (LQ054_14055) | 7199..8626 | - | 1428 | WP_032495690.1 | chloramphenicol/florfenicol efflux MFS transporter FexA | - |
| LQ054_RS14060 (LQ054_14060) | 9366..9464 | + | 99 | WP_086131521.1 | JAB domain-containing protein | - |
| LQ054_RS14065 (LQ054_14065) | 9596..10276 | + | 681 | WP_013646119.1 | IS6-like element IS1216 family transposase | - |
| LQ054_RS14070 (LQ054_14070) | 10318..10938 | + | 621 | WP_249455885.1 | IS6 family transposase | - |
| LQ054_RS14075 (LQ054_14075) | 11205..12068 | - | 864 | WP_077495093.1 | zeta toxin family protein | Toxin |
| LQ054_RS14080 (LQ054_14080) | 12070..12342 | - | 273 | WP_031644662.1 | antitoxin | Antitoxin |
| LQ054_RS14085 (LQ054_14085) | 12360..12575 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| LQ054_RS14090 (LQ054_14090) | 12667..13563 | - | 897 | WP_249455886.1 | ParA family protein | - |
| LQ054_RS14095 (LQ054_14095) | 13666..13926 | - | 261 | Protein_15 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LQ054_RS14100 (LQ054_14100) | 14096..14833 | - | 738 | WP_141062714.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| LQ054_RS14105 (LQ054_14105) | 14958..15026 | - | 69 | WP_011100846.1 | 23S rRNA methyltransferase attenuator leader peptide ErmL | - |
| LQ054_RS14110 (LQ054_14110) | 15090..15329 | - | 240 | WP_002425012.1 | peptide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | Cfr(D) / poxtA / fexA / erm(B) | - | 1..18962 | 18962 | |
| - | inside | IScluster/Tn | Cfr(D) / poxtA / fexA / erm(B) | - | 2763..14833 | 12070 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32489.07 Da Isoelectric Point: 8.2810
>T233011 WP_077495093.1 NZ_CP091236:c12068-11205 [Enterococcus faecalis]
MANIVNFTDKQFENRLRDNIEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIYEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKSYETKMYVMAVPKIESYLGTIERYE
TMFSDEPLTARATPKQAHDIVVKNLPINLDKLHKTGLFSDIRLYNRSGVKLYSSSETPSISPKETLERELNRKLSGKEIQ
PTLERVEQKMIQNKHQEAPEFKAIQQKLESLQPPTPPIPKTPKLPGI
MANIVNFTDKQFENRLRDNIEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIYEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKSYETKMYVMAVPKIESYLGTIERYE
TMFSDEPLTARATPKQAHDIVVKNLPINLDKLHKTGLFSDIRLYNRSGVKLYSSSETPSISPKETLERELNRKLSGKEIQ
PTLERVEQKMIQNKHQEAPEFKAIQQKLESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
>T233011 NZ_CP128516:c2270014-2269745 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10735.36 Da Isoelectric Point: 8.3744
>AT233011 WP_031644662.1 NZ_CP091236:c12342-12070 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKDNSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLKKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKDNSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLKKEKVA
Download Length: 273 bp
>AT233011 NZ_CP128516:c2270267-2270001 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|