Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1559596..1560733 Replicon chromosome
Accession NZ_CP091235
Organism Enterococcus faecalis strain 705

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag LQ054_RS07520 Protein ID WP_002401483.1
Coordinates 1559596..1560459 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag LQ054_RS07525 Protein ID WP_000301765.1
Coordinates 1560461..1560733 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ054_RS07495 (1555202) 1555202..1556065 - 864 WP_002382350.1 DNA-processing protein DprA -
LQ054_RS07500 (1556126) 1556126..1556893 - 768 WP_002357481.1 ribonuclease HII -
LQ054_RS07505 (1556895) 1556895..1557746 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
LQ054_RS07510 (1558022) 1558022..1558453 - 432 Protein_1451 ketopantoate reductase C-terminal domain-containing protein -
LQ054_RS07515 (1558509) 1558509..1559189 - 681 WP_010713944.1 IS6-like element IS1216 family transposase -
LQ054_RS07520 (1559596) 1559596..1560459 - 864 WP_002401483.1 zeta toxin family protein Toxin
LQ054_RS07525 (1560461) 1560461..1560733 - 273 WP_000301765.1 antitoxin Antitoxin
LQ054_RS07530 (1560750) 1560750..1560965 - 216 WP_002295735.1 peptide-binding protein -
LQ054_RS07535 (1561064) 1561064..1561960 - 897 WP_002387620.1 ParA family protein -
LQ054_RS07540 (1562063) 1562063..1562323 - 261 Protein_1457 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LQ054_RS07545 (1562493) 1562493..1563230 - 738 WP_249455861.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
LQ054_RS07550 (1563355) 1563355..1563435 - 81 WP_032501554.1 23S rRNA methyltransferase attenuator leader peptide ErmL -
LQ054_RS07555 (1563531) 1563531..1563653 - 123 Protein_1460 peptide-binding protein -
LQ054_RS07560 (1563773) 1563773..1565299 - 1527 WP_256128437.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat - 1558509..1590725 32216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T233000 WP_002401483.1 NZ_CP091235:c1560459-1559596 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T233000 NZ_CP128515:c1251810-1251634 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT233000 WP_000301765.1 NZ_CP091235:c1560733-1560461 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT233000 NZ_CP128515:c1251578-1251162 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References