Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1559596..1560733 | Replicon | chromosome |
| Accession | NZ_CP091235 | ||
| Organism | Enterococcus faecalis strain 705 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LQ054_RS07520 | Protein ID | WP_002401483.1 |
| Coordinates | 1559596..1560459 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | LQ054_RS07525 | Protein ID | WP_000301765.1 |
| Coordinates | 1560461..1560733 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ054_RS07495 (1555202) | 1555202..1556065 | - | 864 | WP_002382350.1 | DNA-processing protein DprA | - |
| LQ054_RS07500 (1556126) | 1556126..1556893 | - | 768 | WP_002357481.1 | ribonuclease HII | - |
| LQ054_RS07505 (1556895) | 1556895..1557746 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| LQ054_RS07510 (1558022) | 1558022..1558453 | - | 432 | Protein_1451 | ketopantoate reductase C-terminal domain-containing protein | - |
| LQ054_RS07515 (1558509) | 1558509..1559189 | - | 681 | WP_010713944.1 | IS6-like element IS1216 family transposase | - |
| LQ054_RS07520 (1559596) | 1559596..1560459 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| LQ054_RS07525 (1560461) | 1560461..1560733 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| LQ054_RS07530 (1560750) | 1560750..1560965 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| LQ054_RS07535 (1561064) | 1561064..1561960 | - | 897 | WP_002387620.1 | ParA family protein | - |
| LQ054_RS07540 (1562063) | 1562063..1562323 | - | 261 | Protein_1457 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LQ054_RS07545 (1562493) | 1562493..1563230 | - | 738 | WP_249455861.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| LQ054_RS07550 (1563355) | 1563355..1563435 | - | 81 | WP_032501554.1 | 23S rRNA methyltransferase attenuator leader peptide ErmL | - |
| LQ054_RS07555 (1563531) | 1563531..1563653 | - | 123 | Protein_1460 | peptide-binding protein | - |
| LQ054_RS07560 (1563773) | 1563773..1565299 | - | 1527 | WP_256128437.1 | type IA DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat | - | 1558509..1590725 | 32216 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T233000 WP_002401483.1 NZ_CP091235:c1560459-1559596 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T233000 NZ_CP128515:c1251810-1251634 [Mannheimia haemolytica]
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA
GTGAAGCAAAGCGAATTCCTAAGGTGGCTAAAGGCTAATGGGGTAGAGGTTGAAAATGGATCAAAGCATTTGAAACTCTA
CTACAAGGGCAAAAGAAGCCACCTCCCCAAACACCCAAGCCAAGAGTTAAAAACAGGCTTAGTGGAAGGGGTTAAAAAGC
AACTAGGCTTAAAATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT233000 WP_000301765.1 NZ_CP091235:c1560733-1560461 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT233000 NZ_CP128515:c1251578-1251162 [Mannheimia haemolytica]
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA
ATGTTTTATCCAGCGTTATTTACCCCCGCTGAAGAAGGGGGCTTTGTAGTGACATTTCCTGATTTGCCAGAAGCTATCAC
CCAAGGCGATACATTTGAAGAAGCAATGGAAATGGCAGAAGACGTGCTACTATCTTGTGTTGAAATTTATTTCGATGAAG
ATAGACGCTTTCCGCTCACTCGCCCAGTAAATACCGACGAAGTGCCTGTGTTTATGCCAGAGAGCATCTACGCAAAAGTG
CTTTTGCATAATACAATGCAAGAACAAGCGGTAAGCAAGGCAGAAATTGCCCGATTAACTAATATCCGTCCGCCAGAAGT
ACAGCGAATTTTAGCCCCTCGCCATATTACAAAAATCGACACTATTGGTCGTATTTTGGCTAGCTTAGGAAAGCCCCTAC
AACTATCCCTAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|