Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 2853863..2854434 | Replicon | chromosome |
Accession | NZ_CP091231 | ||
Organism | Enterococcus faecalis strain 732 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | R3GRA7 |
Locus tag | LQ055_RS14105 | Protein ID | WP_002360937.1 |
Coordinates | 2853863..2854204 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S4CGQ1 |
Locus tag | LQ055_RS14110 | Protein ID | WP_002367500.1 |
Coordinates | 2854204..2854434 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQ055_RS14100 (2849878) | 2849878..2853492 | - | 3615 | WP_002389470.1 | DNA-directed RNA polymerase subunit beta | - |
LQ055_RS14105 (2853863) | 2853863..2854204 | - | 342 | WP_002360937.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
LQ055_RS14110 (2854204) | 2854204..2854434 | - | 231 | WP_002367500.1 | hypothetical protein | Antitoxin |
LQ055_RS14115 (2854489) | 2854489..2854668 | - | 180 | WP_111997057.1 | hypothetical protein | - |
LQ055_RS14120 (2854848) | 2854848..2855063 | - | 216 | WP_002354768.1 | zinc ribbon domain-containing protein | - |
LQ055_RS14125 (2855202) | 2855202..2856194 | + | 993 | WP_002389493.1 | biotin--[acetyl-CoA-carboxylase] ligase | - |
LQ055_RS14130 (2856458) | 2856458..2857096 | - | 639 | WP_002378863.1 | lytic polysaccharide monooxygenase | - |
LQ055_RS14135 (2857782) | 2857782..2859398 | + | 1617 | WP_002389442.1 | phosphatase PAP2/LCP family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13165.41 Da Isoelectric Point: 9.3988
>T232978 WP_002360937.1 NZ_CP091231:c2854204-2853863 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF
Download Length: 342 bp
>T232978 NZ_CP128508:2401149-2401442 [Pseudomonas asiatica]
GTGCCACGACTGATTGTCACTGAAGGCGCGGCGAAGGGCTTGGAGCGTTGCCGGCGATTCCTCTCCGATAAAGATCCGCA
GGTCGCGCGCCGCGCTGCACAGGCAATCGAGCGCCAATTCGTTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCACCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA
GTGCCACGACTGATTGTCACTGAAGGCGCGGCGAAGGGCTTGGAGCGTTGCCGGCGATTCCTCTCCGATAAAGATCCGCA
GGTCGCGCGCCGCGCTGCACAGGCAATCGAGCGCCAATTCGTTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCATTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCACCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8704.69 Da Isoelectric Point: 4.3313
>AT232978 WP_002367500.1 NZ_CP091231:c2854434-2854204 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF
Download Length: 231 bp
>AT232978 NZ_CP128508:2400889-2401161 [Pseudomonas asiatica]
ATGGCCACTTCCATCAAAATTGACGACGAGCTGAAAGGTCGCATTCAGCATTTGGCTGGTTTGCGGCAGCGTTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGCGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCGTATCAGGAAACCGGCAGGCATTTGACCGGCCAAGAGGCTCGCACCTGGCTTGGTAGCTGGGGTACAGAT
GCTGAGGCAGAGCTTCCCAAGTGCCACGACTGA
ATGGCCACTTCCATCAAAATTGACGACGAGCTGAAAGGTCGCATTCAGCATTTGGCTGGTTTGCGGCAGCGTTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGCGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCGTATCAGGAAACCGGCAGGCATTTGACCGGCCAAGAGGCTCGCACCTGGCTTGGTAGCTGGGGTACAGAT
GCTGAGGCAGAGCTTCCCAAGTGCCACGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2A7G9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S4CGQ1 |