Detailed information of TA system TA023293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 1136582..1137164
• Replicon: chromosome
• Accession: NC_011729
• Organism: Cyanothece sp. PCC 7424

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B7KJN6
• Locus tag: PCC7424_RS05055
• Protein ID: WP_012598432.1
• Coordinates: 1136582..1136932 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B7KJN7
• Locus tag: PCC7424_RS05060
• Protein ID: WP_012598433.1
• Coordinates: 1136922..1137164 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC7424_RS05035	1131930..1132868	-	939	WP_012598428.1	protein translocase subunit SecF	-
PCC7424_RS05040	1132920..1134335	-	1416	WP_012598429.1	protein translocase subunit SecD	-
PCC7424_RS05045	1134437..1135411	-	975	WP_012598430.1	alpha-ketoacid dehydrogenase subunit beta	-
PCC7424_RS05050	1135715..1136503	-	789	WP_012598431.1	MOSC N-terminal beta barrel domain-containing protein	-
PCC7424_RS05055	1136582..1136932	-	351	WP_012598432.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PCC7424_RS05060	1136922..1137164	-	243	WP_012598433.1	hypothetical protein	Antitoxin
PCC7424_RS05065	1137181..1137438	-	258	WP_012598434.1	hypothetical protein	-
PCC7424_RS05070	1137756..1139204	+	1449	WP_041238016.1	RecQ family ATP-dependent DNA helicase	-
PCC7424_RS31310	1139306..1139446	-	141	WP_012598436.1	hypothetical protein	-
PCC7424_RS29690	1139451..1139540	-	90	WP_008277373.1	cytochrome b6-f complex subunit PetN	-
PCC7424_RS05075	1139631..1140047	+	417	WP_012598437.1	hypothetical protein	-
PCC7424_RS05080	1140160..1140702	+	543	WP_012598438.1	DUF2808 domain-containing protein	-
PCC7424_RS05085	1140950..1141792	+	843	WP_012598439.1	serine protease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-99)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13239.01 Da
• Isoelectric Point: 5.2168

>T23293 WP_012598432.1 NC_011729:c1136932-1136582 [Gloeothece citriformis PCC 7424]
MPNESPLVNIDLSPESKRNLRDLAKRYRNIRSDIEPVIEQIQVGDFIGDRISGLGEEYRIYKVRVKNSNIQKGKSGGYRL
IYQVESPTSVLLLTIYSKSDQEDLTANDILDIINQV

Nucleotide

• Length: 351 bp

>T23293 NC_011729:c1136932-1136582 [Gloeothece citriformis PCC 7424]
ATGCCGAATGAAAGTCCGTTAGTTAATATTGATCTTTCTCCTGAGTCTAAACGAAATCTAAGGGATTTGGCTAAAAGATA
TCGTAACATTCGCTCTGATATTGAGCCAGTTATTGAACAAATTCAGGTAGGTGATTTTATTGGCGATCGCATTTCAGGAC
TAGGGGAAGAATACAGGATTTATAAAGTTAGAGTAAAAAATAGCAATATTCAAAAAGGAAAAAGCGGAGGATATCGACTG
ATTTATCAAGTAGAATCTCCGACAAGTGTTTTACTTCTAACAATTTATTCCAAATCCGATCAAGAAGATCTTACAGCAAA
TGATATCCTTGATATTATCAATCAGGTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8921.06 Da
• Isoelectric Point: 4.0480

>AT23293 WP_012598433.1 NC_011729:c1137164-1136922 [Gloeothece citriformis PCC 7424]
MKAFEVTGTIDEKGQLLLDEPLSISSSSVRVIILVNEQDEPDPDDTPIEEIKASLRRALQEAKEGKRIPLSQMWEGIDAE

Nucleotide

• Length: 243 bp

>AT23293 NC_011729:c1137164-1136922 [Gloeothece citriformis PCC 7424]
ATGAAAGCTTTTGAAGTTACCGGAACAATTGATGAAAAAGGGCAATTATTACTCGATGAACCTTTAAGTATATCTTCGAG
TTCGGTTAGGGTAATTATTCTAGTTAATGAGCAAGATGAACCCGATCCTGATGATACTCCTATAGAAGAGATCAAAGCAA
GTCTTAGGAGAGCATTACAGGAAGCTAAAGAGGGTAAAAGAATTCCTTTATCCCAAATGTGGGAGGGAATAGATGCCGAA
TGA

Structures

Toxin

• AlphaFold DB: B7KJN6

Antitoxin

• AlphaFold DB: B7KJN7