Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1178031..1178524 Replicon chromosome
Accession NZ_CP091221
Organism Enterococcus faecium strain 642

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQ060_RS05695 Protein ID WP_002292138.1
Coordinates 1178258..1178524 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ060_RS05690 Protein ID WP_002292139.1
Coordinates 1178031..1178261 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ060_RS05660 (LQ060_05660) 1173073..1174002 + 930 WP_104835589.1 hypothetical protein -
LQ060_RS05665 (LQ060_05665) 1174386..1175021 - 636 WP_104835590.1 ImmA/IrrE family metallo-endopeptidase -
LQ060_RS05670 (LQ060_05670) 1175330..1176295 - 966 WP_219842316.1 protein kinase family protein -
LQ060_RS05675 (LQ060_05675) 1176442..1176699 - 258 WP_104835591.1 Cro/Cl family transcriptional regulator -
LQ060_RS05680 (LQ060_05680) 1176874..1177539 + 666 WP_002292140.1 hypothetical protein -
LQ060_RS05685 (LQ060_05685) 1177581..1177877 + 297 WP_104835592.1 hypothetical protein -
LQ060_RS05690 (LQ060_05690) 1178031..1178261 + 231 WP_002292139.1 DUF6290 family protein Antitoxin
LQ060_RS05695 (LQ060_05695) 1178258..1178524 + 267 WP_002292138.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ060_RS05700 (LQ060_05700) 1178776..1179003 + 228 WP_002308982.1 hypothetical protein -
LQ060_RS05705 (LQ060_05705) 1179019..1180185 + 1167 WP_002292137.1 radical SAM family heme chaperone HemW -
LQ060_RS05710 (LQ060_05710) 1180419..1181462 + 1044 WP_002292136.1 heat-inducible transcriptional repressor HrcA -
LQ060_RS05715 (LQ060_05715) 1181556..1182119 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10556.21 Da        Isoelectric Point: 10.3338

>T232928 WP_002292138.1 NZ_CP091221:1178258-1178524 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Download         Length: 267 bp

>T232928 NZ_CP128477:4245519-4245818 [Rhizobium sp. SSM4.3]
GTGGCTGAGGTCAGGCTCAGTCCCGCCGCACGACGAGACTTTCTGGACATCGGTGACTACACGCGGGACCTATGGTTAGA
AGCTCAGGCGGAGCGTTACCTCCGGCAAATCCTGGGCATCATTGCCGACATCGGAACGCATCCGTTTTCGGGTGGTGAGG
TGGGAGCACTTCGACAAGGCTATCGCCGCCGCCGGTCTGGTTCACATCTGAGTTTCTACATCATTCTTGAGGATGGCATG
GTCGAAGTCATCCGCATCATCCACGAGCGGGCAGACGTCTCGCGCCGGCTGGACGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8883.02 Da        Isoelectric Point: 4.1943

>AT232928 WP_002292139.1 NZ_CP091221:1178031-1178261 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Download         Length: 231 bp

>AT232928 NZ_CP128477:4245275-4245526 [Rhizobium sp. SSM4.3]
ATGAACAAGCCCGTTCAGGTCACCATCGCCGAGCCCTATGACAGCTTTATCGACTCTCAGTTCGAAAGCGGAGCGTTCAA
GTCGGCGCAAGAAGTGGTCGAGGGGGGCTTGCGGCTTCTCAAGGGAGAGCAGGCCAGGGCCGAATGGCTGCGCAAGGCGT
TGATCGAGGGCGAGAACAGCGGGCCGTCCGTGCCGTTCGATCCAGAAGACCTCATGGCTTCCGTTGGTGAAAGATGGAAA
AGCCGTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References