Detailed information of TA system TA232928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1178031..1178524
• Replicon: chromosome
• Accession: NZ_CP091221
• Organism: Enterococcus faecium strain 642

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LQ060_RS05695
• Protein ID: WP_002292138.1
• Coordinates: 1178258..1178524 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LQ060_RS05690
• Protein ID: WP_002292139.1
• Coordinates: 1178031..1178261 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ060_RS05660 (LQ060_05660)	1173073..1174002	+	930	WP_104835589.1	hypothetical protein	-
LQ060_RS05665 (LQ060_05665)	1174386..1175021	-	636	WP_104835590.1	ImmA/IrrE family metallo-endopeptidase	-
LQ060_RS05670 (LQ060_05670)	1175330..1176295	-	966	WP_219842316.1	protein kinase family protein	-
LQ060_RS05675 (LQ060_05675)	1176442..1176699	-	258	WP_104835591.1	Cro/Cl family transcriptional regulator	-
LQ060_RS05680 (LQ060_05680)	1176874..1177539	+	666	WP_002292140.1	hypothetical protein	-
LQ060_RS05685 (LQ060_05685)	1177581..1177877	+	297	WP_104835592.1	hypothetical protein	-
LQ060_RS05690 (LQ060_05690)	1178031..1178261	+	231	WP_002292139.1	DUF6290 family protein	Antitoxin
LQ060_RS05695 (LQ060_05695)	1178258..1178524	+	267	WP_002292138.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LQ060_RS05700 (LQ060_05700)	1178776..1179003	+	228	WP_002308982.1	hypothetical protein	-
LQ060_RS05705 (LQ060_05705)	1179019..1180185	+	1167	WP_002292137.1	radical SAM family heme chaperone HemW	-
LQ060_RS05710 (LQ060_05710)	1180419..1181462	+	1044	WP_002292136.1	heat-inducible transcriptional repressor HrcA	-
LQ060_RS05715 (LQ060_05715)	1181556..1182119	+	564	WP_002292135.1	nucleotide exchange factor GrpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10556.21 Da
• Isoelectric Point: 10.3338

>T232928 WP_002292138.1 NZ_CP091221:1178258-1178524 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQIVVIAIQV
GHRKNVYD

Nucleotide

• Length: 267 bp

>T232928 NZ_CP128477:4245519-4245818 [Rhizobium sp. SSM4.3]
GTGGCTGAGGTCAGGCTCAGTCCCGCCGCACGACGAGACTTTCTGGACATCGGTGACTACACGCGGGACCTATGGTTAGA
AGCTCAGGCGGAGCGTTACCTCCGGCAAATCCTGGGCATCATTGCCGACATCGGAACGCATCCGTTTTCGGGTGGTGAGG
TGGGAGCACTTCGACAAGGCTATCGCCGCCGCCGGTCTGGTTCACATCTGAGTTTCTACATCATTCTTGAGGATGGCATG
GTCGAAGTCATCCGCATCATCCACGAGCGGGCAGACGTCTCGCGCCGGCTGGACGAGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8883.02 Da
• Isoelectric Point: 4.1943

>AT232928 WP_002292139.1 NZ_CP091221:1178031-1178261 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILREFGGLE

Nucleotide

• Length: 231 bp

>AT232928 NZ_CP128477:4245275-4245526 [Rhizobium sp. SSM4.3]
ATGAACAAGCCCGTTCAGGTCACCATCGCCGAGCCCTATGACAGCTTTATCGACTCTCAGTTCGAAAGCGGAGCGTTCAA
GTCGGCGCAAGAAGTGGTCGAGGGGGGCTTGCGGCTTCTCAAGGGAGAGCAGGCCAGGGCCGAATGGCTGCGCAAGGCGT
TGATCGAGGGCGAGAACAGCGGGCCGTCCGTGCCGTTCGATCCAGAAGACCTCATGGCTTCCGTTGGTGAAAGATGGAAA
AGCCGTGGCTGA