Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 474833..475404 | Replicon | chromosome |
Accession | NZ_CP091217 | ||
Organism | Enterococcus faecium strain 1525 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A828ZXV4 |
Locus tag | LQ058_RS02245 | Protein ID | WP_002302307.1 |
Coordinates | 475063..475404 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A828ZZN9 |
Locus tag | LQ058_RS02240 | Protein ID | WP_002323011.1 |
Coordinates | 474833..475063 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQ058_RS02215 (LQ058_02215) | 470322..471650 | + | 1329 | WP_010718318.1 | FAD-dependent oxidoreductase | - |
LQ058_RS02220 (LQ058_02220) | 471672..472298 | + | 627 | WP_002286816.1 | cysteine hydrolase | - |
LQ058_RS02225 (LQ058_02225) | 472481..473062 | + | 582 | WP_043902871.1 | TetR/AcrR family transcriptional regulator | - |
LQ058_RS02230 (LQ058_02230) | 473427..474002 | + | 576 | WP_010718317.1 | SOS response-associated peptidase family protein | - |
LQ058_RS02235 (LQ058_02235) | 474207..474545 | - | 339 | WP_002286804.1 | hypothetical protein | - |
LQ058_RS02240 (LQ058_02240) | 474833..475063 | + | 231 | WP_002323011.1 | hypothetical protein | Antitoxin |
LQ058_RS02245 (LQ058_02245) | 475063..475404 | + | 342 | WP_002302307.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
LQ058_RS02250 (LQ058_02250) | 476254..476439 | + | 186 | WP_002304207.1 | hypothetical protein | - |
LQ058_RS02260 (LQ058_02260) | 477958..478200 | + | 243 | Protein_448 | LPXTG cell wall anchor domain-containing protein | - |
LQ058_RS02265 (LQ058_02265) | 478274..479167 | + | 894 | WP_002326335.1 | class C sortase | - |
LQ058_RS02270 (LQ058_02270) | 479350..480024 | + | 675 | WP_002291233.1 | response regulator transcription factor | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13288.65 Da Isoelectric Point: 9.9044
>T232926 WP_002302307.1 NZ_CP091217:475063-475404 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
Download Length: 342 bp
>T232926 NZ_CP128470:c1822060-1821719 [Macrococcus bovicus]
ATGAGGCGCGGCGAAGTCTTTCTGGCTGACCTGTCACCTGTCAAAGGCTCGGAACAAGGCGGTAAGCGTCCTGTTGTCAT
TATTCAGAATGATGTCGGGAATAAATACAGTCCGACAGTCATCGTGGCTGCAATCACAGCGAAAATCAATAAAGCACGGA
TCCCGACCCATGTGGAGATCGGCAAGACCAACCATCATCTGGATAAGGATTCGGTGATATTGCTTGAACAGATCAGAACG
ATTGATAAAAATCGACTGATTGAAAAGCTGACAGTTCTCTCTGAAGAAAAAATGAGTGAAGTGAATCAGGCGCTGGCCAT
CAGCCTTGGACTCTCTCAATGA
ATGAGGCGCGGCGAAGTCTTTCTGGCTGACCTGTCACCTGTCAAAGGCTCGGAACAAGGCGGTAAGCGTCCTGTTGTCAT
TATTCAGAATGATGTCGGGAATAAATACAGTCCGACAGTCATCGTGGCTGCAATCACAGCGAAAATCAATAAAGCACGGA
TCCCGACCCATGTGGAGATCGGCAAGACCAACCATCATCTGGATAAGGATTCGGTGATATTGCTTGAACAGATCAGAACG
ATTGATAAAAATCGACTGATTGAAAAGCTGACAGTTCTCTCTGAAGAAAAAATGAGTGAAGTGAATCAGGCGCTGGCCAT
CAGCCTTGGACTCTCTCAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8523.39 Da Isoelectric Point: 3.9078
>AT232926 WP_002323011.1 NZ_CP091217:474833-475063 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
Download Length: 231 bp
>AT232926 NZ_CP128470:c1822204-1822061 [Macrococcus bovicus]
ATGAAGAAATTTGATCAATTATTAGCTGAAGGCTATGAATCCATGGCTGAACTTAATTTAATCATTTCTTATGAGCAATT
CGATCTTGAAAGTGAAGTGTGTGAAAAGAGTGAAATGTACGATTTAGCTGATGATGGTGAGTAA
ATGAAGAAATTTGATCAATTATTAGCTGAAGGCTATGAATCCATGGCTGAACTTAATTTAATCATTTCTTATGAGCAATT
CGATCTTGAAAGTGAAGTGTGTGAAAAGAGTGAAATGTACGATTTAGCTGATGATGGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXV4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZZN9 |