Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 184996..185525 Replicon chromosome
Accession NZ_CP091217
Organism Enterococcus faecium strain 1525

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag LQ058_RS00920 Protein ID WP_002294198.1
Coordinates 185259..185525 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag LQ058_RS00915 Protein ID WP_002294199.1
Coordinates 184996..185259 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ058_RS00905 (LQ058_00905) 182371..184194 + 1824 WP_002294202.1 APC family permease -
LQ058_RS00910 (LQ058_00910) 184336..184521 - 186 WP_002294201.1 hypothetical protein -
LQ058_RS00915 (LQ058_00915) 184996..185259 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LQ058_RS00920 (LQ058_00920) 185259..185525 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
LQ058_RS00925 (LQ058_00925) 185726..186214 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LQ058_RS00930 (LQ058_00930) 186756..187427 - 672 WP_002319469.1 ABC transporter permease -
LQ058_RS00935 (LQ058_00935) 187424..188341 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
LQ058_RS00940 (LQ058_00940) 188338..188979 - 642 WP_002293405.1 ABC transporter permease -
LQ058_RS00945 (LQ058_00945) 188983..190158 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T232925 WP_002294198.1 NZ_CP091217:185259-185525 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T232925 NZ_CP128469:61131-61478 [Macrococcus bovicus]
ATGGTAAGTAAAGTATCACAAGGCGATATCTTCTATGTGAATTTTAACCCGAGTCGAGGTCATGAGCAGAAGAACCATAG
GCCAGCTCTTGCTATCAGTCACGATATGGTAAGGGATAACAGCGATATGACGATTGTTGTCCCTATATCTCAGACAGATC
GTGATTTTCCCATGTATTATCCTCTTACAACCACACAATTAGTTAAAGGAAAGGTTCTGTTAGATCAATCTATAGCATTA
GATTTAACGGCTAGAAATGTGACAGCAGATGAAGTGGTTGAAACCTTGTCAAAAGAGGAACTTGAAAAAATAATTAATCG
TTATAAACTGTTGTTCACAATAGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT232925 WP_002294199.1 NZ_CP091217:184996-185259 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT232925 NZ_CP128469:60874-61137 [Macrococcus bovicus]
ATGACGACATTAGAAGCTAAGACAAAGATCACAGGGTGGGGTAATTCAAAAGGCCTGAGAATACCGAGGAAATTTCTTGA
AACATTGCACATCAGTGATAATCAGGAAATGCAGATTAGTGTCAAGAATAATTCACTAGTGATAACACCGGTTACAGAAG
AGCCTAATTCGATCCATGAGTTATTTGCAGGATGGAAAGATGACGGTATACGAGGAAACGAACTGGATTGGGGAATGGCA
AAAGGAGAAGAGCTGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References