Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 180870..181399 Replicon chromosome
Accession NZ_CP091210
Organism Enterococcus faecium strain 211b

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag LQ064_RS00900 Protein ID WP_002294198.1
Coordinates 181133..181399 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag LQ064_RS00895 Protein ID WP_002294199.1
Coordinates 180870..181133 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ064_RS00885 (LQ064_00885) 178245..180068 + 1824 WP_002294202.1 APC family permease -
LQ064_RS00890 (LQ064_00890) 180210..180395 - 186 WP_002294201.1 hypothetical protein -
LQ064_RS12670 180402..180530 + 129 WP_002294200.1 hypothetical protein -
LQ064_RS00895 (LQ064_00895) 180870..181133 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LQ064_RS00900 (LQ064_00900) 181133..181399 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
LQ064_RS00905 (LQ064_00905) 181600..182088 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LQ064_RS00910 (LQ064_00910) 182630..183301 - 672 WP_002319469.1 ABC transporter permease -
LQ064_RS00915 (LQ064_00915) 183298..184215 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
LQ064_RS00920 (LQ064_00920) 184212..184853 - 642 WP_002293405.1 ABC transporter permease -
LQ064_RS00925 (LQ064_00925) 184857..186032 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T232920 WP_002294198.1 NZ_CP091210:181133-181399 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T232920 NZ_CP128466:4223918-4224136 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT232920 WP_002294199.1 NZ_CP091210:180870-181133 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT232920 NZ_CP128466:4223517-4223891 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References