232917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 999705..1000234 Replicon chromosome
Accession NZ_CP091206
Organism Enterococcus faecium strain 1818

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag LQ061_RS04730 Protein ID WP_002294198.1
Coordinates 999705..999971 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag LQ061_RS04735 Protein ID WP_002294199.1
Coordinates 999971..1000234 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ061_RS04705 (LQ061_04710) 995072..996247 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
LQ061_RS04710 (LQ061_04715) 996251..996892 + 642 WP_002293405.1 ABC transporter permease -
LQ061_RS04715 (LQ061_04720) 996889..997806 + 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
LQ061_RS04720 (LQ061_04725) 997803..998474 + 672 WP_002319469.1 ABC transporter permease -
LQ061_RS04725 (LQ061_04730) 999016..999504 - 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
LQ061_RS04730 (LQ061_04735) 999705..999971 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
LQ061_RS04735 (LQ061_04740) 999971..1000234 - 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LQ061_RS12845 1000574..1000702 - 129 WP_002294200.1 hypothetical protein -
LQ061_RS04740 (LQ061_04745) 1000709..1000894 + 186 WP_002294201.1 hypothetical protein -
LQ061_RS04745 (LQ061_04750) 1001036..1002859 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T232917 WP_002294198.1 NZ_CP091206:c999971-999705 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T232917 NZ_CP128466:1930066-1930168 [Klebsiella variicola]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT232917 WP_002294199.1 NZ_CP091206:c1000234-999971 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT232917 NZ_CP128466:c1930174-1930030 [Klebsiella variicola]
ACCGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References