Detailed information of TA system TA023291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 3041565..3041995
• Replicon: chromosome
• Accession: NC_011726
• Organism: Cyanothece sp. PCC 8801

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PCC8801_RS14365
• Protein ID: WP_012596205.1
• Coordinates: 3041771..3041995 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B7JW93
• Locus tag: PCC8801_RS14360
• Protein ID: WP_012596204.1
• Coordinates: 3041565..3041771 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PCC8801_RS14340	3037076..3038719	-	1644	WP_012596200.1	cation:proton antiporter	-
PCC8801_RS14345	3038969..3039406	+	438	WP_012596201.1	pentapeptide repeat-containing protein	-
PCC8801_RS14350	3039697..3040566	-	870	WP_012596202.1	lipoyl synthase	-
PCC8801_RS14355	3040989..3041270	+	282	WP_012596203.1	hypothetical protein	-
PCC8801_RS14360	3041565..3041771	+	207	WP_012596204.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PCC8801_RS14365	3041771..3041995	+	225	WP_012596205.1	type II toxin-antitoxin system HicA family toxin	Toxin
PCC8801_RS14370	3042016..3042459	-	444	WP_012596206.1	DUF29 domain-containing protein	-
PCC8801_RS14375	3042562..3043455	+	894	WP_012596207.1	CoB--CoM heterodisulfide reductase iron-sulfur subunit B family protein	-
PCC8801_RS14380	3043461..3044027	-	567	WP_012596208.1	Uma2 family endonuclease	-
PCC8801_RS14385	3044065..3044355	+	291	WP_012596209.1	acylphosphatase	-
PCC8801_RS14390	3044434..3045183	-	750	WP_012596210.1	tetratricopeptide repeat protein	-
PCC8801_RS14395	3045395..3045721	+	327	WP_012596211.1	septal ring lytic transglycosylase RlpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-58)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8122.41 Da
• Isoelectric Point: 6.4628

>T23291 WP_012596205.1 NC_011726:3041771-3041995 [Rippkaea orientalis PCC 8801]
MGSALPIMSGREVVRVFESLGWEAVRQTGSHIIMTKDEELVTLSIPDHREVAKGTLRSLIRTAGLTVEEFVAAK

Nucleotide

• Length: 225 bp

>T23291 NC_011726:3041771-3041995 [Rippkaea orientalis PCC 8801]
ATGGGTTCTGCTTTACCTATCATGAGTGGCCGCGAAGTTGTGCGCGTCTTTGAATCGTTGGGTTGGGAAGCTGTGCGGCA
GACGGGTAGCCACATCATCATGACGAAGGATGAAGAACTTGTCACGCTTTCGATTCCTGATCACCGTGAAGTGGCGAAAG
GAACCTTGCGAAGTTTGATTCGCACTGCTGGATTAACGGTAGAGGAATTTGTTGCTGCCAAGTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7481.53 Da
• Isoelectric Point: 4.1435

>AT23291 WP_012596204.1 NC_011726:3041565-3041771 [Rippkaea orientalis PCC 8801]
MRFSVTLDRDEDGVWVVECPSIPGCVSQGQTKQEALENIKDAIAACLQVRAERGMPLTVETYQVEVVA

Nucleotide

• Length: 207 bp

>AT23291 NC_011726:3041565-3041771 [Rippkaea orientalis PCC 8801]
ATGAGGTTTAGCGTCACGCTTGATCGCGATGAGGATGGAGTTTGGGTTGTGGAGTGCCCCAGTATTCCAGGATGTGTGAG
TCAAGGTCAGACGAAACAAGAAGCCCTCGAAAATATCAAAGATGCGATCGCTGCGTGTCTACAGGTTCGGGCAGAACGCG
GGATGCCGCTGACTGTAGAAACCTATCAGGTCGAGGTTGTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: B7JW93