Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1764110..1764600 Replicon chromosome
Accession NZ_CP091198
Organism Enterococcus faecalis strain UK045

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag L2629_RS09415 Protein ID WP_002358470.1
Coordinates 1764331..1764600 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L2629_RS09410 Protein ID WP_229240809.1
Coordinates 1764110..1764331 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2629_RS09385 (1760248) 1760248..1760778 + 531 WP_002358466.1 hypothetical protein -
L2629_RS09390 (1760793) 1760793..1761617 + 825 WP_002358467.1 hypothetical protein -
L2629_RS09395 (1761993) 1761993..1762256 + 264 WP_002358468.1 hypothetical protein -
L2629_RS09400 (1762249) 1762249..1762806 + 558 WP_002358242.1 hypothetical protein -
L2629_RS09405 (1762809) 1762809..1764044 + 1236 WP_010717251.1 MobP2 family relaxase -
L2629_RS09410 (1764110) 1764110..1764331 + 222 WP_229240809.1 DUF6290 family protein Antitoxin
L2629_RS09415 (1764331) 1764331..1764600 + 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2629_RS09420 (1764667) 1764667..1766247 + 1581 WP_002404807.1 DUF3991 domain-containing protein -
L2629_RS09425 (1766255) 1766255..1766968 + 714 WP_002358472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-69)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T232909 WP_002358470.1 NZ_CP091198:1764331-1764600 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

>T232909 NZ_CP128464:2769699-2769842 [Enterococcus faecalis]
ATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8583.63 Da        Isoelectric Point: 4.0179

>AT232909 WP_229240809.1 NZ_CP091198:1764110-1764331 [Enterococcus faecalis]
MITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 222 bp

>AT232909 NZ_CP128464:c2769958-2769775 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAA
TCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure

References