Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2569995..2570401 Replicon chromosome
Accession NC_011726
Organism Cyanothece sp. PCC 8801

Toxin (Protein)


Gene name hicA Uniprot ID B7K3V5
Locus tag PCC8801_RS12145 Protein ID WP_012595762.1
Coordinates 2569995..2570186 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B7K3V6
Locus tag PCC8801_RS12150 Protein ID WP_012595763.1
Coordinates 2570186..2570401 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC8801_RS12125 2565767..2566855 - 1089 WP_012595758.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
PCC8801_RS12130 2567128..2568081 - 954 WP_012595759.1 zinc ABC transporter substrate-binding protein -
PCC8801_RS12135 2568196..2568936 + 741 WP_012595760.1 metal ABC transporter ATP-binding protein -
PCC8801_RS12140 2568938..2569663 - 726 WP_012595761.1 DUF928 domain-containing protein -
PCC8801_RS12145 2569995..2570186 + 192 WP_012595762.1 type II toxin-antitoxin system HicA family toxin Toxin
PCC8801_RS12150 2570186..2570401 + 216 WP_012595763.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PCC8801_RS12155 2570436..2573288 - 2853 WP_012595764.1 CHAT domain-containing protein -
PCC8801_RS12160 2573363..2574754 - 1392 WP_012595765.1 TldD/PmbA family protein -
PCC8801_RS23240 2574837..2574980 - 144 WP_157861302.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-60)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7008.27 Da        Isoelectric Point: 10.9310

>T23290 WP_012595762.1 NC_011726:2569995-2570186 [Rippkaea orientalis PCC 8801]
MKVKDVLKRLKADGWYQVRMRGSHRILAHPTKSGIVVVPGKLSNDIPIGTLSAIWKQAQLGDE

Download         Length: 192 bp

>T23290 NC_011726:2569995-2570186 [Rippkaea orientalis PCC 8801]
ATGAAAGTTAAAGACGTGCTAAAGCGACTCAAAGCAGATGGATGGTATCAAGTTAGGATGAGGGGTAGTCATCGAATTTT
AGCGCATCCTACCAAGTCAGGAATTGTTGTCGTTCCAGGAAAATTGAGTAATGATATTCCTATTGGAACTTTATCAGCTA
TTTGGAAACAAGCACAATTAGGAGATGAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7882.03 Da        Isoelectric Point: 4.0236

>AT23290 WP_012595763.1 NC_011726:2570186-2570401 [Rippkaea orientalis PCC 8801]
MKQYAVIYEKGQTNWGAIVPDLPGCVSIGDSFEEVQENVKEAIALYLEVLEERGEKIPEPLTKVGLVDIFA

Download         Length: 216 bp

>AT23290 NC_011726:2570186-2570401 [Rippkaea orientalis PCC 8801]
ATGAAGCAGTATGCTGTCATTTATGAAAAGGGTCAGACAAATTGGGGGGCAATTGTTCCTGATTTGCCAGGTTGTGTTAG
CATTGGTGATTCATTCGAGGAAGTGCAGGAAAATGTCAAAGAAGCGATCGCACTTTATTTAGAGGTTTTAGAAGAAAGAG
GTGAAAAGATTCCTGAACCTTTAACTAAGGTAGGATTAGTTGATATATTCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7K3V5

Antitoxin

Source ID Structure
AlphaFold DB B7K3V6

References