Detailed information of TA system TA232882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ImmA-IrrE/Peptidase_M78-HTH_19
• Location: 851280..851975
• Replicon: chromosome
• Accession: NZ_CP091198
• Organism: Enterococcus faecalis strain UK045

Toxin (Protein)

• Gene name: IrrE
• Uniprot ID: -
• Locus tag: L2629_RS04845
• Protein ID: WP_010708389.1
• Coordinates: 851631..851975 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ImmA
• Uniprot ID: -
• Locus tag: L2629_RS04840
• Protein ID: WP_016024366.1
• Coordinates: 851280..851612 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2629_RS04785 (847144)	847144..848085	-	942	WP_236335318.1	YqaJ viral recombinase family protein	-
L2629_RS04790 (848183)	848183..848410	-	228	WP_002364220.1	hypothetical protein	-
L2629_RS04795 (848410)	848410..848733	-	324	WP_002380444.1	hypothetical protein	-
L2629_RS04800 (848777)	848777..848962	-	186	WP_002364222.1	hypothetical protein	-
L2629_RS04805 (848953)	848953..849147	-	195	WP_002364223.1	hypothetical protein	-
L2629_RS04810 (849200)	849200..849382	+	183	WP_002364224.1	YegP family protein	-
L2629_RS04815 (849422)	849422..850144	-	723	WP_125203802.1	ORF6C domain-containing protein	-
L2629_RS04820 (850098)	850098..850259	-	162	WP_010708394.1	hypothetical protein	-
L2629_RS04825 (850270)	850270..850446	-	177	WP_010708393.1	helix-turn-helix transcriptional regulator	-
L2629_RS04830 (850524)	850524..850802	+	279	WP_010708392.1	hypothetical protein	-
L2629_RS04835 (850799)	850799..850960	-	162	WP_010708391.1	hypothetical protein	-
L2629_RS04840 (851280)	851280..851612	+	333	WP_016024366.1	helix-turn-helix transcriptional regulator	Antitoxin
L2629_RS04845 (851631)	851631..851975	+	345	WP_010708389.1	ImmA/IrrE family metallo-endopeptidase	Toxin
L2629_RS04850 (852077)	852077..853444	+	1368	WP_010708388.1	recombinase family protein	-
L2629_RS04855 (853466)	853466..854041	-	576	WP_002393061.1	DNA repair protein RadC	-
L2629_RS04860 (854073)	854073..854732	-	660	WP_002385286.1	HAD family hydrolase	-
L2629_RS04865 (854716)	854716..856038	-	1323	WP_002355117.1	folylpolyglutamate synthase/dihydrofolate synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (5-59)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13459.46 Da
• Isoelectric Point: 5.2082

>T232882 WP_010708389.1 NZ_CP091198:851631-851975 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLHKKACFEPKYGVIFINQDLSTAEQEEAIYHEFKHVKDHADLMALYNIPIFRSKMEAEAEQ
YMLECLIEKNGGQFNYSNVITHYNLKMGQEIYLK

Nucleotide

• Length: 345 bp

>T232882 NZ_CP128435:421903-422178 [Morganella morganii subsp. morganii]
ATGGAAGTTTATTGGACGCTTAAAGCTCAGGATGACCTGGAGCGTATCTACCGTTTTGCCCTTCAGTACAGCCGCCAGCA
CGCCGATGACGTTTTGGATCGCCTGATGACTGGTTGTGCTGGTCTTACAGCGAATCCGGCAATTGGCATACAGCAGACTC
GGTATGAACCTCGTGAGGTCCGAAAAGTATTATTCGATGATTACGAGGTTCACTACGAACTTCGCGATAGTGACATCTAT
ATCGTGGATCTCTGGCATACCAAAGAAGAACGATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12589.28 Da
• Isoelectric Point: 5.2520

>AT232882 WP_016024366.1 NZ_CP091198:851280-851612 [Enterococcus faecalis]
MTAFDRIKKITDRRGISINELENRVGISQNVLYGWKKKTPGGENLTKVAKYLNISTDYILGIVDNPEPFVEKKTDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Nucleotide

• Length: 333 bp

>AT232882 NZ_CP128435:421651-421899 [Morganella morganii subsp. morganii]
ATGGGTTCGCTTACTAAACAAACCATTAGCGCACAGATACCTGTTGAGTTGGCTGCTGCTGTTGAAAATCTGGCAATTGA
GTTGGACCGTTCTAAGAGCTGGATTATTAAAGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCATCAGAGCA
TTCAGGCCGGTCTTGCCGATGTGGATGCTGGTCGCGTGGTGAGCCACTCGGACATGGTGGATTTTGCTAATCGCTTAAAG
AAATCCTGA