Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_26(antitoxin) |
| Location | 725601..726299 | Replicon | chromosome |
| Accession | NZ_CP091198 | ||
| Organism | Enterococcus faecalis strain UK045 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A059N529 |
| Locus tag | L2629_RS04085 | Protein ID | WP_002373917.1 |
| Coordinates | 725955..726299 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | L2629_RS04080 | Protein ID | WP_002388206.1 |
| Coordinates | 725601..725936 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2629_RS04025 (720817) | 720817..721632 | - | 816 | WP_010706853.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
| L2629_RS04030 (721595) | 721595..722566 | - | 972 | WP_010706854.1 | RecT family recombinase | - |
| L2629_RS04035 (722659) | 722659..723015 | - | 357 | WP_010706855.1 | hypothetical protein | - |
| L2629_RS04040 (723018) | 723018..723242 | - | 225 | WP_002367281.1 | hypothetical protein | - |
| L2629_RS04045 (723239) | 723239..723538 | - | 300 | WP_010706856.1 | hypothetical protein | - |
| L2629_RS04050 (723625) | 723625..724041 | - | 417 | WP_002417286.1 | hypothetical protein | - |
| L2629_RS04055 (724042) | 724042..724212 | - | 171 | WP_010706857.1 | hypothetical protein | - |
| L2629_RS04060 (724247) | 724247..724516 | - | 270 | WP_002365131.1 | hypothetical protein | - |
| L2629_RS04065 (724534) | 724534..724713 | - | 180 | WP_229202013.1 | DUF2829 domain-containing protein | - |
| L2629_RS04070 (724776) | 724776..725114 | - | 339 | WP_010706859.1 | hypothetical protein | - |
| L2629_RS04075 (725127) | 725127..725309 | - | 183 | WP_002388205.1 | hypothetical protein | - |
| L2629_RS04080 (725601) | 725601..725936 | + | 336 | WP_002388206.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L2629_RS04085 (725955) | 725955..726299 | + | 345 | WP_002373917.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| L2629_RS04090 (726328) | 726328..726726 | + | 399 | WP_010706860.1 | hypothetical protein | - |
| L2629_RS04095 (726744) | 726744..727475 | + | 732 | WP_010706861.1 | potassium channel family protein | - |
| L2629_RS04100 (727630) | 727630..728811 | + | 1182 | WP_002365138.1 | site-specific integrase | - |
| L2629_RS04105 (728914) | 728914..729063 | - | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 654988..728811 | 73823 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6177
>T232881 WP_002373917.1 NZ_CP091198:725955-726299 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
Download Length: 345 bp
>T232881 NZ_CP128435:420285-420626 [Morganella morganii subsp. morganii]
ATGAAAACTTTACCTGCATCAACTCTGCGGGCGGCTAAGCCATGCCCGACGCCCGTAGTTGTCTGGCAAACGCTACTTAC
GCGCCTGCTGGGGCAACACTATGGCCTGACGCTGAACGACACGCCGTTCAGTGATGAGAACGTTATTCAGGAGCATATCA
ACGCCGGTATTACGCTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGATTT
AGCAGGCAGGAACAATCGCCTTATCTGCGGGCTGTAGACATTTTGCGGGCGCGACAGGCAACGGGTCTGTTGCGGCGAAG
TCATCATCCTTCGACGCGCTGA
ATGAAAACTTTACCTGCATCAACTCTGCGGGCGGCTAAGCCATGCCCGACGCCCGTAGTTGTCTGGCAAACGCTACTTAC
GCGCCTGCTGGGGCAACACTATGGCCTGACGCTGAACGACACGCCGTTCAGTGATGAGAACGTTATTCAGGAGCATATCA
ACGCCGGTATTACGCTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGATTT
AGCAGGCAGGAACAATCGCCTTATCTGCGGGCTGTAGACATTTTGCGGGCGCGACAGGCAACGGGTCTGTTGCGGCGAAG
TCATCATCCTTCGACGCGCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12842.51 Da Isoelectric Point: 5.2926
>AT232881 WP_002388206.1 NZ_CP091198:725601-725936 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK
Download Length: 336 bp
>AT232881 NZ_CP128435:419923-420249 [Morganella morganii subsp. morganii]
ATGGAGAAAAACGATCCCATCGAATGGGGGCTTCGACGCGATATCACGCCGCGTGTAGGAGCACGGCTGGTACAGGAAAG
AAATCAATTGCATTACCTGGCTGACCGGGCCGGTGTCACCGGCATTTTTAATGAAGCTGAGAGCCGCAAACTGAATGCAG
CATTTCCGCATTTCGTGGAGCAGATGGAGTTAATGCTACTCTCCGGGGAACTAAACCCCCGTTATGCGCACTGTGTCACC
CTGTACCATGATGGATTTACCTGTGAAGCTGACACGCTTGGCTCTTATGGTTACGTCTACATCGTCATTTACCCTACTCA
ACGCTGA
ATGGAGAAAAACGATCCCATCGAATGGGGGCTTCGACGCGATATCACGCCGCGTGTAGGAGCACGGCTGGTACAGGAAAG
AAATCAATTGCATTACCTGGCTGACCGGGCCGGTGTCACCGGCATTTTTAATGAAGCTGAGAGCCGCAAACTGAATGCAG
CATTTCCGCATTTCGTGGAGCAGATGGAGTTAATGCTACTCTCCGGGGAACTAAACCCCCGTTATGCGCACTGTGTCACC
CTGTACCATGATGGATTTACCTGTGAAGCTGACACGCTTGGCTCTTATGGTTACGTCTACATCGTCATTTACCCTACTCA
ACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|