Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 78996..79567 Replicon plasmid pUK045_1
Accession NZ_CP091197
Organism Enterococcus faecalis strain UK045

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L2629_RS00415 Protein ID WP_010775693.1
Coordinates 78996..79337 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L2629_RS00420 Protein ID WP_010775692.1
Coordinates 79337..79567 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2629_RS00390 (L2629_00385) 74052..74810 - 759 WP_236334659.1 abortive infection system toxin AbiGii family protein -
L2629_RS00395 (L2629_00390) 74812..75543 - 732 WP_174080465.1 abortive infection system antitoxin AbiGi family protein -
L2629_RS00400 (L2629_00395) 75597..76787 - 1191 WP_002324630.1 IS256-like element ISLgar5 family transposase -
L2629_RS00405 (L2629_00400) 77097..77699 - 603 WP_104866331.1 Fic family protein -
L2629_RS00410 (L2629_00405) 77946..78884 - 939 WP_104866332.1 hypothetical protein -
L2629_RS00415 (L2629_00410) 78996..79337 - 342 WP_010775693.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L2629_RS00420 (L2629_00415) 79337..79567 - 231 WP_010775692.1 hypothetical protein Antitoxin
L2629_RS00425 (L2629_00420) 79797..80402 + 606 WP_000599739.1 Fic family protein -
L2629_RS00430 (L2629_00425) 80418..80990 + 573 WP_000170424.1 recombinase family protein -
L2629_RS00435 (L2629_00430) 81423..82382 - 960 WP_000222577.1 IS30-like element IS1252 family transposase -
L2629_RS00440 (L2629_00435) 82510..83190 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
L2629_RS00445 (L2629_00440) 83418..83693 - 276 WP_001196543.1 DNA segregation protein PrgO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90994 90994
- inside IScluster/Tn - - 72784..87576 14792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13224.42 Da        Isoelectric Point: 8.8595

>T232880 WP_010775693.1 NZ_CP091197:c79337-78996 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDTSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T232880 NZ_CP091197:c79337-78996 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATACTTCAGCTGGAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACAATGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATAAAAAATATGCCCACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGATTTTACAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8494.42 Da        Isoelectric Point: 4.3855

>AT232880 WP_010775692.1 NZ_CP091197:c79567-79337 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGAEGEYYEKDEWHDIEPGGRELF

Download         Length: 231 bp

>AT232880 NZ_CP091197:c79567-79337 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAACAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTTCCTAAATTACAAGATCCATTTAGTGGGG
GAGCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References