Detailed information of TA system TA232874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 134351..134910
• Replicon: chromosome
• Accession: NZ_CP091186
• Organism: Vibrio anguillarum strain J382

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7YRQ7
• Locus tag: L2O48_RS15065
• Protein ID: WP_010320663.1
• Coordinates: 134351..134629 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A233HRF0
• Locus tag: L2O48_RS15070
• Protein ID: WP_017040620.1
• Coordinates: 134626..134910 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2O48_RS15030 (L2O48_15030)	130221..130574	-	354	WP_011154649.1	IS66 family insertion sequence element accessory protein TnpB	-
L2O48_RS15035 (L2O48_15035)	130571..130888	-	318	WP_011154648.1	hypothetical protein	-
L2O48_RS15040 (L2O48_15040)	130971..131804	-	834	Protein_119	IS30-like element ISVa6 family transposase	-
L2O48_RS15045 (L2O48_15045)	132051..132536	+	486	WP_107489895.1	hypothetical protein	-
L2O48_RS15050 (L2O48_15050)	132542..132658	+	117	WP_088718078.1	DUF3265 domain-containing protein	-
L2O48_RS15055 (L2O48_15055)	132750..133001	+	252	WP_013868555.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
L2O48_RS15060 (L2O48_15060)	132991..133278	+	288	WP_013868556.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L2O48_RS15065 (L2O48_15065)	134351..134629	-	279	WP_010320663.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
L2O48_RS15070 (L2O48_15070)	134626..134910	-	285	WP_017040620.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L2O48_RS15075 (L2O48_15075)	136110..136469	+	360	WP_019281417.1	VOC family protein	-
L2O48_RS15080 (L2O48_15080)	137160..137600	+	441	WP_040122767.1	hypothetical protein	-
L2O48_RS15085 (L2O48_15085)	137757..138224	+	468	WP_001289286.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	123447..138807	15360

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10878.58 Da
• Isoelectric Point: 4.3430

>T232874 WP_010320663.1 NZ_CP091186:c134629-134351 [Vibrio anguillarum]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDDIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGSIIRIM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T232874 NZ_CP128416:3131449-3131787 [Rhizobium sp. CSC1952]
ATGACGTCGGCATCCTATGTTCCGGATGCGGGCGATATCGTCTGGCTGCAATTTTCGCCTCAGGCCGGGCACGGGCAGGT
CGGTCATCGGCCCGCTGTCGTGCTCACCCCCGCGAGCTACAACCGTTTCAGGCTCATGCTGTGTTGTCCCATGACGACCA
AGCGCAAGGGATATCCCTTCGAGGTCGCGATTGCCGGCGATCGGGAAAGCGTCGTTCTGGCTGACCAAGTCAAAAGCCTG
GATTGGCGGGCGCGCAATGCCCAGCGCAAGGGGCGTGTTTCGGACCATGAGCTTGGCGAAGTAAGAGCGAAAGCCGCGGC
GCTGATCGGAAAACCCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10957.29 Da
• Isoelectric Point: 9.2173

>AT232874 WP_017040620.1 NZ_CP091186:c134910-134626 [Vibrio anguillarum]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDAWLTEQINLAFEKFDSGKSSFVEHNSAKAR
MAERKAKIRNRGQQ

Nucleotide

• Length: 285 bp

>AT232874 NZ_CP128416:3131210-3131452 [Rhizobium sp. CSC1952]
ATGCGCGTCACCGTGAAAAAGTGGGGAAACAGCGCGTCCGTGCGGATTCCTGCAGCGGTGATGGAGGCTGCCCGGCTGGA
GGTCGACGCGGTGGTGGACGTATCCGAGGAGAATGGCCGGATCGTCATCGAGCCGATACGGGATGCGGAATTCGACCTCG
ACAAGCTCATTGCGGGCATCACGCCCGAGAACCTGCATGAGGAAGTCGATTTCGGTGGGCCGGTCGGCAAGGAAACCCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0F2IQF3

Antitoxin

• AlphaFold DB: A0A233HRF0