Detailed information of TA system TA232873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 132750..133278
• Replicon: chromosome
• Accession: NZ_CP091186
• Organism: Vibrio anguillarum strain J382

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7YRA6
• Locus tag: L2O48_RS15060
• Protein ID: WP_013868556.1
• Coordinates: 132991..133278 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F7YRA5
• Locus tag: L2O48_RS15055
• Protein ID: WP_013868555.1
• Coordinates: 132750..133001 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2O48_RS15020 (L2O48_15020)	127986..128261	+	276	WP_013868550.1	hypothetical protein	-
L2O48_RS15025 (L2O48_15025)	128620..130161	-	1542	WP_011154650.1	IS66-like element ISVa5 family transposase	-
L2O48_RS15030 (L2O48_15030)	130221..130574	-	354	WP_011154649.1	IS66 family insertion sequence element accessory protein TnpB	-
L2O48_RS15035 (L2O48_15035)	130571..130888	-	318	WP_011154648.1	hypothetical protein	-
L2O48_RS15040 (L2O48_15040)	130971..131804	-	834	Protein_119	IS30-like element ISVa6 family transposase	-
L2O48_RS15045 (L2O48_15045)	132051..132536	+	486	WP_107489895.1	hypothetical protein	-
L2O48_RS15050 (L2O48_15050)	132542..132658	+	117	WP_088718078.1	DUF3265 domain-containing protein	-
L2O48_RS15055 (L2O48_15055)	132750..133001	+	252	WP_013868555.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L2O48_RS15060 (L2O48_15060)	132991..133278	+	288	WP_013868556.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L2O48_RS15065 (L2O48_15065)	134351..134629	-	279	WP_010320663.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
L2O48_RS15070 (L2O48_15070)	134626..134910	-	285	WP_017040620.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
L2O48_RS15075 (L2O48_15075)	136110..136469	+	360	WP_019281417.1	VOC family protein	-
L2O48_RS15080 (L2O48_15080)	137160..137600	+	441	WP_040122767.1	hypothetical protein	-
L2O48_RS15085 (L2O48_15085)	137757..138224	+	468	WP_001289286.1	OsmC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	123447..138807	15360

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11064.07 Da
• Isoelectric Point: 10.5506

>T232873 WP_013868556.1 NZ_CP091186:132991-133278 [Vibrio anguillarum]
MTYKLKFLPAAKKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Nucleotide

• Length: 288 bp

>T232873 NZ_CP128416:2260378-2260674 [Rhizobium sp. CSC1952]
ATGGCGCCTAAGCGATATCGGCTATCGCCCCAGGCCAGAAAAGATCTTGAGGGCATCTGGCTCTACACTTTCAAGACATG
GTCCCGAGTGCAGGCCGACGGGTATTATGACGAATTGATCGCGGCTGTTGCAGATTTGGCGAACGGCTCCAAACGCGGAA
GAATGATCGACAATATCCGGTCCGGCTATCTCAGCCTGTCTTACGGTTCGCATTTCATCATCTACAAACAAGGCGCAACC
GGAATCAACGTCGTCCGCATCCTGCACCAGCGGATGAACATCAGCCGCCATCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9154.36 Da
• Isoelectric Point: 4.0414

>AT232873 WP_013868555.1 NZ_CP091186:132750-133001 [Vibrio anguillarum]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVNI
DDL

Nucleotide

• Length: 252 bp

>AT232873 NZ_CP128416:2260143-2260388 [Rhizobium sp. CSC1952]
ATGGGCAAGATGACATCGATCACGGTGGATGAGGAACTGACGGCCTTCATCGCCAAGCAGGTGAGCGACGGCAACTATAG
CTCCGCAGATGAAGTCGTGGAAGCAGCACTGCGGCTTTTGCGCGACAGCGAGGATGGGCTTGAAGCCATCCGGGCCGCCA
TCGACGAGGGCGAAGCATCAGGCGAGCCGGAACCTTTCGATGCGGAAGCGTTTCTGCAGGAGATGCATCGCAAATATGGC
GCCTAA

Structures

Toxin

• AlphaFold DB: A0A1E5BHG0

Antitoxin

• AlphaFold DB: A0A7X8TZB8