Detailed information of TA system TA232871

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2044726..2046290
• Replicon: chromosome
• Accession: NZ_CP091176
• Organism: Aeromonas caviae strain SCLZS52

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4TP05
• Locus tag: L1871_RS09805
• Protein ID: WP_005329232.1
• Coordinates: 2044726..2046036 (-)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L1871_RS09810
• Protein ID: WP_005329233.1
• Coordinates: 2046036..2046290 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1871_RS09790 (L1871_09785)	2040578..2041540	+	963	WP_223918491.1	IS1595 family transposase	-
L1871_RS09795 (L1871_09790)	2041596..2043770	-	2175	WP_236276976.1	catalase/peroxidase HPI	-
L1871_RS09805 (L1871_09800)	2044726..2046036	-	1311	WP_005329232.1	type II toxin-antitoxin system HipA family toxin	Toxin
L1871_RS09810 (L1871_09805)	2046036..2046290	-	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
L1871_RS09815 (L1871_09810)	2046792..2047040	+	249	WP_010674978.1	hypothetical protein	-
L1871_RS09820 (L1871_09815)	2047461..2047712	-	252	WP_010674977.1	plasmid stabilization protein	-
L1871_RS09825 (L1871_09820)	2047791..2049098	-	1308	WP_021140687.1	Fic family protein	-
L1871_RS09830 (L1871_09825)	2049353..2049805	+	453	WP_021140686.1	DUF2384 domain-containing protein	-
L1871_RS09835 (L1871_09830)	2050137..2050715	+	579	WP_021140685.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2023123..2052225	29102
	-	flank	IS/Tn	-	-	2040578..2041540	962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49096.31 Da
• Isoelectric Point: 7.1717

>T232871 WP_005329232.1 NZ_CP091176:c2046036-2044726 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T232871 NZ_CP128416:1289727-1290014 [Rhizobium sp. CSC1952]
ATGGCCGAGAAACTTTCGAACTACGATCCCGCGGAAGACCTTGGCTCGGACGAAGCGATCGCCACCTTCATGGCGGAAGC
TTTCGAGACGGAGGACGCTGCCTATATCGCGCATGCGCTCGGCGTCGTCGCGCGCGCCAAAGGCATGACCCAGATCGCCA
AGGATACCGGCCTTTCGCGCGAGCAGCTCTACCGTTCCTTCAGCGCAACCGGCAATCCGACACTCAAAACAACGATCGCC
GTGATGAAGTCGCTGGGCATCGGGCTCACGGCCAAGGTCCACTCGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT232871 WP_005329233.1 NZ_CP091176:c2046290-2046036 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT232871 NZ_CP128416:1289431-1289727 [Rhizobium sp. CSC1952]
GTGTTCGAGCTCAAGCAAACGGAAGCCTTCCGCAAGTGGCGCACGGGTCTGAGAGACGACCGCGCCCGAGCGATGATTGC
TTCCCGGCTCGACCGCCTCGCCTTCGGGCATGCTGGCGATGTGGCGCCGGTCGGTGATGGAGTCAGCGAGCTGCGTATTC
ACTACGGGCCTGGCTACCGCATCTATTTCCAGCAACGCGGCAACCTCCTGATCGTACTTCTGTGCGGAGGCGACAAGAGC
AGCCAGGCAAGGGACATCAAGCTCGCGAAAAAGCTCTCGCAGGAATGGAGTGAATGA

Structures

Toxin

• AlphaFold DB: A0A2S4TP05