Detailed information of TA system TA232866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2046038..2047674
• Replicon: chromosome
• Accession: NZ_CP091173
• Organism: Acinetobacter baumannii strain AB5116

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9F1U5K1
• Locus tag: L2M54_RS09975
• Protein ID: WP_005128640.1
• Coordinates: 2046343..2047674 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L2M54_RS09970
• Protein ID: WP_001101310.1
• Coordinates: 2046038..2046346 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2M54_RS09945 (L2M54_09945)	2041402..2042115	+	714	WP_005128644.1	hypothetical protein	-
L2M54_RS09950 (L2M54_09950)	2042128..2043237	+	1110	WP_005128643.1	XRE family transcriptional regulator	-
L2M54_RS09955 (L2M54_09955)	2043300..2043848	-	549	WP_005128641.1	TetR/AcrR family transcriptional regulator	-
L2M54_RS09960 (L2M54_09960)	2044271..2044780	+	510	WP_001122273.1	helix-turn-helix domain-containing protein	-
L2M54_RS09965 (L2M54_09965)	2044813..2045655	+	843	WP_223673390.1	IS3 family transposase	-
L2M54_RS09970 (L2M54_09970)	2046038..2046346	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
L2M54_RS09975 (L2M54_09975)	2046343..2047674	-	1332	WP_005128640.1	HipA domain-containing protein	Toxin
L2M54_RS09980 (L2M54_09980)	2047970..2048410	+	441	WP_000193136.1	HD domain-containing protein	-
L2M54_RS09985 (L2M54_09985)	2048445..2049089	-	645	WP_005128638.1	hypothetical protein	-
L2M54_RS09990 (L2M54_09990)	2049101..2050072	-	972	WP_086267245.1	5'/3'-nucleotidase SurE	-
L2M54_RS09995 (L2M54_09995)	2050199..2051362	-	1164	WP_005128635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.25 Da
• Isoelectric Point: 4.8549

>T232866 WP_005128640.1 NZ_CP091173:c2047674-2046343 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T232866 NZ_CP128416:41789-42046 [Rhizobium sp. CSC1952]
ATGAAGATCACTTATGACGAAAACAAGCGCCTGACCAATATCGAGAAGCACTTCGGCCTCGACTTTGCCGATCTCGATAT
GGATTTCTTCGAAGGCGCGACGATCTATCCAGCAAAGGACGACCGCCTCATGGCGATCGGTGAATTCAAAGGCCAGATCA
TCCTCGTCGTGATCTTCAAGCCGCTTGGATCGGAAGCCATTTCCGTCATCTCAATGCGGCACGCAAGCAGGAAGGAAAGG
GAAACCCATGGCTACTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT232866 WP_001101310.1 NZ_CP091173:c2046346-2046038 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT232866 NZ_CP128416:42036-42356 [Rhizobium sp. CSC1952]
ATGGCTACTAAGTTTTCAGCGAAACGCCCGCTAACCGATGCGGAAGAAGCCGAAATCCAGAAGGCTATCGCATCCGATCC
GGACTCCCCGGAAGCTACCGATGAGCAGCTTGCCAAGGGTAGGCCATTCCGTGAAGCTCTACCTGAGCTGGCAGCAAGCA
TTGACCGGGAAAGAGCTAGGCGCGGCCGACCTCCCGTTGAGAAGCCTCGTCAGCATGTATCTCTGCGCCTCGATCCCGAT
GTTATCGACCACTACAAGGCAACCGGCAAAGGCTGGCAGAGCCGAATGAATGATGATCTACGTAAGGCTGCCGGCCTGTA
A