Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3650788..3651441 Replicon chromosome
Accession NZ_CP091172
Organism Acinetobacter baumannii strain MRSN57

Toxin (Protein)


Gene name cptA Uniprot ID B0V6V2
Locus tag LQS91_RS17885 Protein ID WP_000931890.1
Coordinates 3650788..3651177 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag LQS91_RS17890 Protein ID WP_001288210.1
Coordinates 3651184..3651441 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQS91_RS17870 (LQS91_17870) 3645906..3648101 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
LQS91_RS17875 (LQS91_17875) 3648289..3648855 - 567 WP_000651536.1 rhombosortase -
LQS91_RS17880 (LQS91_17880) 3648933..3650018 - 1086 WP_000049106.1 hypothetical protein -
LQS91_RS17885 (LQS91_17885) 3650788..3651177 - 390 WP_000931890.1 membrane protein Toxin
LQS91_RS17890 (LQS91_17890) 3651184..3651441 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
LQS91_RS17895 (LQS91_17895) 3651629..3652801 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
LQS91_RS17900 (LQS91_17900) 3652851..3654341 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
LQS91_RS17905 (LQS91_17905) 3654522..3654899 - 378 WP_001216380.1 50S ribosomal protein L17 -
LQS91_RS17910 (LQS91_17910) 3654918..3655925 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T232865 WP_000931890.1 NZ_CP091172:c3651177-3650788 [Acinetobacter baumannii]
MLNHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T232865 NZ_CP128411:562124-562474 [Brevibacillus brevis]
GTGATTGTCAAACGTGGCGATGTGTTTTTCGCGGACCTGTCCCCGGTCGTTGGCTCTGAGCAAGGAGGCGTACGGCCTGT
TTTAGTCATTCAAAACGACATTGGAAATCGATTTAGTCCGACGGTCATCGTCGCAGCCATTACGGCGCAGATTCAAAAGG
CGAAGCTGCCTACGCATGTGGAAATTGACGCAAAAACTTATGGATTTGATCGTGACTCCGTTATTCTGTTGGAACAAATA
CGAACCATTGACAAACAACGTCTAACTGATAAAATTACGCATCTCGATGACGAGATGATGGATCGGGTTAATGAATCCTT
GCAAATCAGTTTAGGACTCATTGATTTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT232865 WP_001288210.1 NZ_CP091172:c3651441-3651184 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT232865 NZ_CP128411:561821-562120 [Brevibacillus brevis]
ATGGTTGGAGGTGGATTTGTCTTGTCGAAGTCAAACACGAAACGCATCATGATCAGCTTGCCACAACACTTGCTTCAGGA
AGTGGATGGCGTTATTCAAAAGGAAAAATCCAATCGCAGCGAGTTTATTCGTCAAGCGATGCATTTGTATTTGAAAGAGC
GAAAAAAACGCACAATCCGTGAGACCATGCAAAAAGGGTACATGGAGATGGCGAAGATCAATCTGAATATGGCATCGGAG
GCTTTTGGCGCTGAAGAAGAGGCTGACCATACTCTTGTCCGCTTAGTTAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1A4U0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References