Detailed information of TA system TA232864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 1334144..1335885
• Replicon: chromosome
• Accession: NZ_CP091172
• Organism: Acinetobacter baumannii strain MRSN57

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: N9S537
• Locus tag: LQS91_RS06775
• Protein ID: WP_000233088.1
• Coordinates: 1334144..1334800 (+)
• Length: 219 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: LQS91_RS06780
• Protein ID: WP_003112112.1
• Coordinates: 1334800..1335885 (+)
• Length: 362 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQS91_RS06765 (LQS91_06765)	1329299..1330669	+	1371	WP_003114524.1	EH signature domain-containing protein	-
LQS91_RS06770 (LQS91_06770)	1330702..1333905	+	3204	WP_003129329.1	DEAD/DEAH box helicase	-
LQS91_RS06775 (LQS91_06775)	1334144..1334800	+	657	WP_000233088.1	DUF4433 domain-containing protein	Toxin
LQS91_RS06780 (LQS91_06780)	1334800..1335885	+	1086	WP_003112112.1	macro domain-containing protein	Antitoxin
LQS91_RS06785 (LQS91_06785)	1336673..1337554	+	882	WP_000732866.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
LQS91_RS06790 (LQS91_06790)	1337679..1337945	-	267	WP_000703423.1	hypothetical protein	-
LQS91_RS06795 (LQS91_06795)	1338609..1339163	+	555	WP_002024621.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (18-218)

Antitoxin

• Macro domain (18-129)

Sequences

Toxin

Protein

• Length: 219 a.a.
• Molecular weight: 25316.92 Da
• Isoelectric Point: 7.1033

>T232864 WP_000233088.1 NZ_CP091172:1334144-1334800 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Nucleotide

• Length: 657 bp

>T232864 NZ_CP128410:156632-156889 [Streptococcus parasuis]
TTGAGTTATAAGGTTATTTTGTCTGCTAGGGTTCAAAAGCAAATTCAAAAAATGGATAAAACGGCTGCAAGTTTGATTTT
GCGGTATCTTTATAAGCATATCGACGGGTGCGACAACCCTAGACAATACGGAATAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGGTACCGTATCGGTAACTACAGAGTTATCGTCAGTATTGAAGATAACAAATTGATTATGACAAGCATAAAAATG
AGAAATGGAAGTCTGTAA

Antitoxin

Protein

• Length: 362 a.a.
• Molecular weight: 41063.20 Da
• Isoelectric Point: 6.0689

>AT232864 WP_003112112.1 NZ_CP091172:1334800-1335885 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYFHTDVT

Nucleotide

• Length: 1086 bp

>AT232864 NZ_CP128410:156403-156642 [Streptococcus parasuis]
ATGGCAGCTATTACATTAAAAGTTTCTGAGCAAGACAAGCTATTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
GTCAGAACTCATCCGGACTAAAACCCTTGCAGCTCTCGAAGATGAATACGATGCCCGCGTGGCAGATATTGCTTGGGCAG
AATACCAAGCTGACTTGGCGAATGGAATTGAGCCGATAACACTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA

Structures

Toxin

• AlphaFold DB: N9S537