Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 7846..8342 Replicon plasmid p2NCPPB4222
Accession NZ_CP091149
Organism Pseudomonas avellanae strain NCPPB 4222

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L2Y01_RS28155 Protein ID WP_024419628.1
Coordinates 7846..8154 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q48BA1
Locus tag L2Y01_RS28160 Protein ID WP_002556028.1
Coordinates 8154..8342 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y01_RS28130 (L2Y01_28130) 2999..4231 - 1233 WP_104742490.1 IS91 family transposase -
L2Y01_RS28135 (L2Y01_28135) 4512..5744 - 1233 WP_104742490.1 IS91 family transposase -
L2Y01_RS28140 (L2Y01_28140) 5756..5956 + 201 WP_249741680.1 hypothetical protein -
L2Y01_RS28145 (L2Y01_28145) 5972..7276 - 1305 WP_145915128.1 hypothetical protein -
L2Y01_RS28150 (L2Y01_28150) 7352..7495 + 144 Protein_9 type II toxin-antitoxin system RelE/ParE family toxin -
L2Y01_RS28155 (L2Y01_28155) 7846..8154 - 309 WP_024419628.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y01_RS28160 (L2Y01_28160) 8154..8342 - 189 WP_002556028.1 hypothetical protein Antitoxin
L2Y01_RS28165 (L2Y01_28165) 8520..8834 - 315 Protein_12 helix-turn-helix domain-containing protein -
L2Y01_RS28170 (L2Y01_28170) 9052..9318 - 267 WP_044423204.1 carbon storage regulator -
L2Y01_RS28175 (L2Y01_28175) 9529..10107 - 579 WP_024420030.1 AAA family ATPase -
L2Y01_RS28180 (L2Y01_28180) 10107..10763 - 657 WP_007247578.1 2OG-Fe(II) oxygenase family protein -
L2Y01_RS28185 (L2Y01_28185) 10800..11595 - 796 Protein_16 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
L2Y01_RS28190 (L2Y01_28190) 11956..12561 + 606 WP_024421557.1 recombinase family protein -
L2Y01_RS28515 12981..13109 + 129 WP_255300967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..50625 50625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11793.52 Da        Isoelectric Point: 7.3147

>T232863 WP_024419628.1 NZ_CP091149:c8154-7846 [Pseudomonas avellanae]
MLPVVWLSPALDDLREIATYIAWENPSAARRLKSLLQEAIEPVAEHPYLYRSGRAPGTRELVAHPNYVLVYRVTLERIEV
VNVIHARQEYPGFGEQWNRKPT

Download         Length: 309 bp

>T232863 NZ_CP128405:c3254781-3254629 [Stenotrophomonas sp. 17(2023)]
ATGAAGCGAGTACTGATGCTGGCCCTGCTGGCGGTGTTTTCGGCGGGGATGCTCAGCGCCTGCAACACCGTCGCCGGCGC
CGGCAAGGACATGCAGAAGGCCGGCGAGAAGGTCGAGGACAAGGCCCACGACTGCAGCGACGGCAAGTGTTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7043.86 Da        Isoelectric Point: 4.2550

>AT232863 WP_002556028.1 NZ_CP091149:c8342-8154 [Pseudomonas avellanae]
MANLSPIVSEFETDEQAASYDRWFRAKVAASLADPRPAIPHDEVMAEIEALIDQVETQREKR

Download         Length: 189 bp

>AT232863 NZ_CP128405:c3254572-3254438 [Stenotrophomonas sp. 17(2023)]
ATGAAGCGCACGGTTGCCCTGATGATGCTGTCGTTGTTCTCGATCGCGGTGCTGTCCGGCTGCAATACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCCGGCGAGAAGGTGGAGGACGCAGCCAAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2G9KWB9

References