Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 1878..2374 | Replicon | plasmid p2NCPPB4222 |
| Accession | NZ_CP091149 | ||
| Organism | Pseudomonas avellanae strain NCPPB 4222 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | L2Y01_RS28120 | Protein ID | WP_249741679.1 |
| Coordinates | 2063..2374 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | L2Y01_RS28115 | Protein ID | WP_080439133.1 |
| Coordinates | 1878..2063 (+) | Length | 62 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Y01_RS28105 (L2Y01_28105) | 1..1314 | + | 1314 | WP_249741678.1 | replication initiation protein | - |
| L2Y01_RS28110 (L2Y01_28110) | 1498..1791 | + | 294 | WP_044425124.1 | HU family DNA-binding protein | - |
| L2Y01_RS28115 (L2Y01_28115) | 1878..2063 | + | 186 | WP_080439133.1 | stability determinant | Antitoxin |
| L2Y01_RS28120 (L2Y01_28120) | 2063..2374 | + | 312 | WP_249741679.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2Y01_RS28125 (L2Y01_28125) | 2443..2886 | + | 444 | WP_283779189.1 | IS5 family transposase | - |
| L2Y01_RS28130 (L2Y01_28130) | 2999..4231 | - | 1233 | WP_104742490.1 | IS91 family transposase | - |
| L2Y01_RS28135 (L2Y01_28135) | 4512..5744 | - | 1233 | WP_104742490.1 | IS91 family transposase | - |
| L2Y01_RS28140 (L2Y01_28140) | 5756..5956 | + | 201 | WP_249741680.1 | hypothetical protein | - |
| L2Y01_RS28145 (L2Y01_28145) | 5972..7276 | - | 1305 | WP_145915128.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..50625 | 50625 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11719.54 Da Isoelectric Point: 6.2150
>T232862 WP_249741679.1 NZ_CP091149:2063-2374 [Pseudomonas avellanae]
MLPIFWLESADNDLAAIIEYIGLRDIAAAERLWQRLRGIVLPLSEHPYLYAISDRVPGMREIVAHPNYLVFYRVTSTRIE
VVNVVHARQEYPQTGLGSVPVST
MLPIFWLESADNDLAAIIEYIGLRDIAAAERLWQRLRGIVLPLSEHPYLYAISDRVPGMREIVAHPNYLVFYRVTSTRIE
VVNVVHARQEYPQTGLGSVPVST
Download Length: 312 bp
>T232862 NZ_CP128405:c3254572-3254438 [Stenotrophomonas sp. 17(2023)]
ATGAAGCGCACGGTTGCCCTGATGATGCTGTCGTTGTTCTCGATCGCGGTGCTGTCCGGCTGCAATACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCCGGCGAGAAGGTGGAGGACGCAGCCAAGCGCTGA
ATGAAGCGCACGGTTGCCCTGATGATGCTGTCGTTGTTCTCGATCGCGGTGCTGTCCGGCTGCAATACCGTTGCCGGTGC
CGGCAAGGACGTGCAGAAGGCCGGCGAGAAGGTGGAGGACGCAGCCAAGCGCTGA
Antitoxin
Download Length: 62 a.a. Molecular weight: 7162.09 Da Isoelectric Point: 6.4675
>AT232862 WP_080439133.1 NZ_CP091149:1878-2063 [Pseudomonas avellanae]
MIDRSPIVSEFETEELEANYTVWLRAKVEASLADSRPAIPHDEVERRMAERLARLRHRRAS
MIDRSPIVSEFETEELEANYTVWLRAKVEASLADSRPAIPHDEVERRMAERLARLRHRRAS
Download Length: 186 bp
>AT232862 NZ_CP128405:c3254781-3254629 [Stenotrophomonas sp. 17(2023)]
ATGAAGCGAGTACTGATGCTGGCCCTGCTGGCGGTGTTTTCGGCGGGGATGCTCAGCGCCTGCAACACCGTCGCCGGCGC
CGGCAAGGACATGCAGAAGGCCGGCGAGAAGGTCGAGGACAAGGCCCACGACTGCAGCGACGGCAAGTGTTGA
ATGAAGCGAGTACTGATGCTGGCCCTGCTGGCGGTGTTTTCGGCGGGGATGCTCAGCGCCTGCAACACCGTCGCCGGCGC
CGGCAAGGACATGCAGAAGGCCGGCGAGAAGGTCGAGGACAAGGCCCACGACTGCAGCGACGGCAAGTGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|