Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 81399..82066 | Replicon | plasmid p1NCPPB4222 |
| Accession | NZ_CP091148 | ||
| Organism | Pseudomonas avellanae strain NCPPB 4222 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A0Q0GBP3 |
| Locus tag | L2Y01_RS27940 | Protein ID | WP_002556038.1 |
| Coordinates | 81399..81815 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | E7PUB4 |
| Locus tag | L2Y01_RS27945 | Protein ID | WP_002556039.1 |
| Coordinates | 81812..82066 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Y01_RS27900 (L2Y01_27900) | 76708..77328 | - | 621 | WP_005747119.1 | recombinase family protein | - |
| L2Y01_RS27905 (L2Y01_27905) | 77537..77875 | + | 339 | WP_024420290.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L2Y01_RS27910 (L2Y01_27910) | 77875..78162 | + | 288 | WP_005622028.1 | XRE family transcriptional regulator | - |
| L2Y01_RS27915 (L2Y01_27915) | 78224..78640 | + | 417 | WP_024420291.1 | TrfB-related DNA-binding protein | - |
| L2Y01_RS27920 (L2Y01_27920) | 79099..79476 | + | 378 | WP_007247501.1 | hypothetical protein | - |
| L2Y01_RS27925 (L2Y01_27925) | 79523..80359 | + | 837 | WP_024420292.1 | DUF932 domain-containing protein | - |
| L2Y01_RS27930 (L2Y01_27930) | 80427..80627 | + | 201 | WP_004666908.1 | hypothetical protein | - |
| L2Y01_RS27935 (L2Y01_27935) | 80676..81137 | + | 462 | WP_249741672.1 | hypothetical protein | - |
| L2Y01_RS27940 (L2Y01_27940) | 81399..81815 | - | 417 | WP_002556038.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| L2Y01_RS27945 (L2Y01_27945) | 81812..82066 | - | 255 | WP_002556039.1 | plasmid stabilization protein | Antitoxin |
| L2Y01_RS27950 (L2Y01_27950) | 82638..83261 | - | 624 | WP_024420277.1 | glycoside hydrolase family 25 protein | - |
| L2Y01_RS27955 (L2Y01_27955) | 83795..84976 | - | 1182 | WP_011169845.1 | glycoside hydrolase family 10 protein | - |
| L2Y01_RS27960 (L2Y01_27960) | 85061..86356 | - | 1296 | WP_024420278.1 | glycoside hydrolase family 68 protein | - |
| L2Y01_RS27965 (L2Y01_27965) | 86368..86553 | - | 186 | WP_024420279.1 | Com family DNA-binding transcriptional regulator | - |
| L2Y01_RS27970 (L2Y01_27970) | 86482..86847 | + | 366 | WP_249740317.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..110191 | 110191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 14865.14 Da Isoelectric Point: 4.6579
>T232861 WP_002556038.1 NZ_CP091148:c81815-81399 [Pseudomonas avellanae]
MIVLDTNVVSEAMKPESHLAVRAWLNDQAAETLYLSSVTLAELLFGIGALPAGKRKDMLAQALDGLMGLFRDRVLPFDID
AARRYADLAVTAKTCGRGFPTPDGYIAAIAASRDFIVASRDTAPYEAVGVPVINPWEV
MIVLDTNVVSEAMKPESHLAVRAWLNDQAAETLYLSSVTLAELLFGIGALPAGKRKDMLAQALDGLMGLFRDRVLPFDID
AARRYADLAVTAKTCGRGFPTPDGYIAAIAASRDFIVASRDTAPYEAVGVPVINPWEV
Download Length: 417 bp
>T232861 NZ_CP128389:c2776193-2775732 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAATCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAATCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9442.84 Da Isoelectric Point: 7.3219
>AT232861 WP_002556039.1 NZ_CP091148:c82066-81812 [Pseudomonas avellanae]
MAMLTVRNLPDDVHRALRVRAAQHGHSTEAEVREILAIAVKPETRVRLGEALAALGRKIGLTNEDFEVFNQVRDKTPAEP
LRFE
MAMLTVRNLPDDVHRALRVRAAQHGHSTEAEVREILAIAVKPETRVRLGEALAALGRKIGLTNEDFEVFNQVRDKTPAEP
LRFE
Download Length: 255 bp
>AT232861 NZ_CP128389:c2776529-2776206 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0GBP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G9L5L9 |