Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239691..240333 Replicon chromosome
Accession NC_011725
Organism Bacillus cereus B4264

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag BCB4264_RS01375 Protein ID WP_000635965.1
Coordinates 239983..240333 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BCB4264_RS01370 Protein ID WP_000004570.1
Coordinates 239691..239978 (+) Length 96 a.a.

Genomic Context


BCB4264_RS01345BCB4264_RS01355BCB4264_RS01360BCB4264_RS01365BCB4264_RS01370BCB4264_RS01375BCB4264_RS01380BCB4264_RS01390BCB4264_RS01350BCB4264_RS01385
Location: 235008..235970 (963 bp)
Type: Others
Protein ID: WP_000961166.1
Location: 236629..236988 (360 bp)
Type: Others
Protein ID: WP_000583415.1
Location: 237145..238095 (951 bp)
Type: Others
Protein ID: WP_002004297.1
Location: 238213..239382 (1170 bp)
Type: Others
Protein ID: WP_000390615.1
Location: 239691..239978 (288 bp)
Type: Antitoxin
Protein ID: WP_000004570.1
Location: 239983..240333 (351 bp)
Type: Toxin
Protein ID: WP_000635965.1
Location: 240401..242569 (2169 bp)
Type: Others
Protein ID: WP_000426237.1
Location: 242939..243397 (459 bp)
Type: Others
Protein ID: WP_000344237.1
Location: 235963..236535 (573 bp)
Type: Others
Protein ID: WP_000908523.1
Location: 242627..242743 (117 bp)
Type: Others
Protein ID: WP_001143642.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BCB4264_RS01345235008..235970+963WP_000961166.1UV DNA damage repair endonuclease UvsE-
BCB4264_RS01350235963..236535-573WP_000908523.1rhomboid family intramembrane serine protease-
BCB4264_RS01355236629..236988+360WP_000583415.1holo-ACP synthase-
BCB4264_RS01360237145..238095+951WP_002004297.1outer membrane lipoprotein carrier protein LolA-
BCB4264_RS01365238213..239382+1170WP_000390615.1alanine racemase-
BCB4264_RS01370239691..239978+288WP_000004570.1antitoxin EndoAIAntitoxin
BCB4264_RS01375239983..240333+351WP_000635965.1type II toxin-antitoxin system endoribonuclease NdoAToxin
BCB4264_RS01380240401..242569+2169WP_000426237.1RNA-binding transcriptional accessory protein-
BCB4264_RS01385242627..242743-117WP_001143642.1cortex morphogenetic protein CmpA-
BCB4264_RS01390242939..243397+459WP_000344237.1SprT family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T23286 WP_000635965.1 NC_011725:239983-240333 [Bacillus cereus B4264]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T23286 NC_011725:239983-240333 [Bacillus cereus B4264]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT23286 WP_000004570.1 NC_011725:239691-239978 [Bacillus cereus B4264]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT23286 NC_011725:239691-239978 [Bacillus cereus B4264]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A366G118


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366FY90

References