Detailed information of TA system TA232859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4953146..4953687
• Replicon: chromosome
• Accession: NZ_CP091147
• Organism: Pseudomonas avellanae strain NCPPB 4222

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0Q0ECV1
• Locus tag: L2Y01_RS22405
• Protein ID: WP_024419858.1
• Coordinates: 4953412..4953687 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L2Y01_RS22400
• Protein ID: WP_081591395.1
• Coordinates: 4953146..4953412 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Y01_RS22390 (L2Y01_22390)	4948820..4950700	-	1881	WP_024419856.1	methyl-accepting chemotaxis protein	-
L2Y01_RS22395 (L2Y01_22395)	4951059..4952981	+	1923	WP_024419857.1	methyl-accepting chemotaxis protein	-
L2Y01_RS22400 (L2Y01_22400)	4953146..4953412	+	267	WP_081591395.1	ribbon-helix-helix domain-containing protein	Antitoxin
L2Y01_RS22405 (L2Y01_22405)	4953412..4953687	+	276	WP_024419858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L2Y01_RS22410 (L2Y01_22410)	4954259..4955527	+	1269	WP_005615053.1	OprD family porin	-
L2Y01_RS22415 (L2Y01_22415)	4955707..4956534	+	828	WP_005615050.1	NAD(P)-dependent oxidoreductase	-
L2Y01_RS22420 (L2Y01_22420)	4956591..4957475	+	885	WP_005615047.1	SMP-30/gluconolactonase/LRE family protein	-
L2Y01_RS22425 (L2Y01_22425)	4957532..4958557	+	1026	WP_005615044.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10710.40 Da
• Isoelectric Point: 7.0121

>T232859 WP_024419858.1 NZ_CP091147:4953412-4953687 [Pseudomonas avellanae]
MELMWTSKALSDVARLYDFLAVANQPAAAQTVQKLTAAPIMLLSNPRIGERLEEFEPRDVRKIQIGRYEMRYEIVDSTIY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T232859 NZ_CP128389:2254638-2255000 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9948.23 Da
• Isoelectric Point: 5.7066

>AT232859 WP_081591395.1 NZ_CP091147:4953146-4953412 [Pseudomonas avellanae]
MTTKTRSVTAHVPEQLAEKVDLMAERLERSKNWIVRQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSLST
ATPLPVPR

Nucleotide

• Length: 267 bp

>AT232859 NZ_CP128389:2254471-2254641 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: A0A0Q0ECV1